The patient is a 57-year-old woman with a history of Hodgkin's lymphoma in remission. A routine analysis found hepatic profile alterations, and a full liver function test showed SOLs in a non-cirrhotic liver. An anatomopathological study revealed metastatic melanoma. The patient was referred to the Departments of Dermatology and Ophthalmology to locate the primary tumor and was diagnosed with stage IV choroidal melanoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.17235/reed.2025.11105/2025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnosis of metastatic melanoma in the liver. where can the primary tumor be found?
Rev Esp Enferm Dig
March 2025
Aparato Digestivo, Complejo Asistencial Universitario de Salamanca.
The patient is a 57-year-old woman with a history of Hodgkin's lymphoma in remission. A routine analysis found hepatic profile alterations, and a full liver function test showed SOLs in a non-cirrhotic liver. An anatomopathological study revealed metastatic melanoma.
View Article and Find Full Text PDFTreatment at the end of life in patients with advanced melanoma. A multicenter DeCOG study of 1067 patients from the prospective skin cancer registry ADOReg.
Front Immunol
March 2025
Department of Dermatology, Gesundheit Nord Klinikverbund Bremen, Bremen, Germany.
Background: Although systemic therapies have improved considerably over the last decade, up to 50% of patients with metastatic melanoma still die due to disease progression. Oncological treatment at the end-of-life phase is challenging. The aim of this study was to investigate the frequency and type of systemic therapy received by melanoma patients in their end-of-life phase.
View Article and Find Full Text PDFNarration of an Uncommon Pediatric Cutaneous Melanoma with Metastasis to Liver: Report of Case with Review on Management Updates.
Indian J Otolaryngol Head Neck Surg
February 2025
General Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh India.
Melanoma is a malignant tumor arising from malignant transformation of melanocytes, and is highly aggressive in nature with increased risk of mortality. A thorough examination of lymph nodes at all levels of the neck and additionally, the parotid gland should be examined. Here we discuss a case of metastatic malignant melanoma of periorbital region in a 10 year old female patient.
View Article and Find Full Text PDFTebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer.
Nat Commun
March 2025
Immunocore Ltd, Abingdon-on-Thames, UK.
Uveal melanoma (UM) is the most common intraocular cancer in adults, with metastatic disease (mUM) occurring in approximately half of the patients. Tebentafusp, an immune-mobilizing monoclonal T cell receptor against cancer (ImmTAC), is a therapeutic shown to improve overall survival (OS) in HLA-A*02:01 adult patients with mUM. Here we investigate the impact of tumor-associated macrophages (TAM) on ImmTAC activity.
View Article and Find Full Text PDFLet-7a microRNA modulates caspase-3-dependent apoptosis in melanoma cells treated with dabrafenib and trametinib combination.
Ir J Med Sci
March 2025
Department of Biology, Faculty of Engineering and Natural Sciences, Celal Bayar University, 45140, Manisa, Türkiye.
Background: Malignant melanoma is an aggressive tumor with high resistance to therapy. The emergence of RAS-driven secondary cancers and BRAF-inhibitor resistance has led to the development of combination therapies targeting both BRAF and MEK.
Aims: This study explored the mechanisms underlying the synergistic effects of dabrafenib (DAB) and trametinib (TM) in drug-resistant A375 and RPMI 7951 melanoma cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!