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Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma.
Elife
March 2025
Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Background: Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). The tumor immune microenvironment (TIME) and tumor heterogeneity are recognized as pivotal factors in cancer progression and therapy. However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood.
View Article and Find Full Text PDFThe value of molecular features in predicting efficacy of immuno-combinations in kidney cancer: just a drop in the ocean?
Expert Rev Mol Diagn
March 2025
Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Background: T-lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with a less favorable prognosis. The genetic background of T-ALL is widely heterogeneous, with the co-occurrence of multiple genetic abnormalities. The STIL-TAL1 rearrangement results from a submicroscopic deletion on chromosome 1p33 and is present in 15 - 25% of T-ALL cases.
View Article and Find Full Text PDFGenomic and proteomic analyses of Nus-dependent non-lambdoid phages reveal a novel coliphage group prevalent in gut: mEp.
Front Microbiol
February 2025
Unidad de Genética, Hospital General de México "Dr. Eduardo Liceaga", México City, México.
Introduction: Nus-dependent Mexican phages (mEp) were previously isolated from clinical samples of human feces. Approximately 50% corresponded to non-lambdoid temperate phages integrating a single immunity group, namely immunity I (mEp), and these were as prevalent as the lambdoid phages identified in such collection.
Methods: In this work, we present the structural and functional characterization of six representative mEp phages (mEp010, mEp013, mEp021, mEp044, mEp515, and mEp554).
Ultrasonography: an aid in molecular subtyping of breast carcinoma.
J Ultrason
January 2025
Radiodiagnosis, Indira Gandhi Medical College and Hospital (IGMC), Shimla, Himachal Pradesh, India.
Introduction: The recognition of molecular subtypes of breast cancer has initiated a new regimen of targeted therapy. Early diagnosis is a key step in improving survival. Therefore, a cost-effective and widely available imaging tool is needed for the timely detection and prediction of the molecular profile of breast cancer.
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