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Mendelian randomization analysis of the causal association between metabolite and skin cancer.
Dermatol Reports
March 2025
Oncology Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province.
Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore the causal association between metabolites and SC risks using a Mendelian randomization (MR) approach.
View Article and Find Full Text PDFCirculating Blood-Based Proteins in Psychopathology and Cognition: A Mendelian Randomization Study.
JAMA Psychiatry
March 2025
Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, New York.
Importance: Peripheral (blood-based) biomarkers for psychiatric illness could benefit diagnosis and treatment, but research to date has typically been low throughput, and traditional case-control studies are subject to potential confounds of treatment and other exposures. Large-scale 2-sample mendelian randomization (MR) can examine the potentially causal impact of circulating proteins on neuropsychiatric phenotypes without these confounds.
Objective: To identify circulating proteins associated with risk for schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) as well as cognitive task performance (CTP).
Association between vitamin D level and risk of type 2 diabetes: a systematic review of Mendelian Randomization studies.
Crit Rev Food Sci Nutr
March 2025
Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong SAR, China.
This study aims to review the evidence from Mendelian randomization (MR) studies on the causal role of vitamin D in type 2 diabetes (T2D). A systematic search (registered on PROSPERO (CRD42024551731)) was performed in PubMed, Embase and Web of Science for publications up to June 2024. MR studies including vitamin D as the exposure and T2D as the outcome were included.
View Article and Find Full Text PDFMediation Analysis of Gut Microbiota and Plasma Metabolites in Asthma Pathogenesis Using Mendelian Randomization.
J Asthma
March 2025
Department of Emergency, Wujin Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, 213017, Jiangsu, China.
Asthma is a prevalent chronic respiratory condition with multifactorial pathogenesis. Emerging evidence suggests that gut microbiota and their metabolites influence asthma risk. This study explores the mediation effects of plasma metabolites between gut microbiota and asthma using Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFExploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.
Neurol Res
March 2025
Neurovascular Center, Naval Medical University Changhai hospital, Shanghai, China.
Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.
Methods: In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases.
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