Background: There is limited research on the Minimal Important Change (MIC) of the Chinese Western Aphasia Battery (WAB). Since an MIC for Chinese WAB has yet to be established, the clinical implications of data using the Chinese WAB remain unclear.
Aim: This study was to establish the MIC of the Aphasia Quotient (AQ) of the Chinese WAB.
Design: The study is a prospective, longitudinal study.
Setting: The rehabilitation department of a Class A tertiary hospital.
Population: One hundred six patients with aphasia after stroke were included and analyzed in the study.
Methods: Patients were evaluated by a speech and language therapist using the Chinese version of WAB before and after the 2 week intervention. Patients and their primary therapist and caregiver provided a global rating of changes in patients' oral communication ability using the 7-point Likert Scale after the speech and language therapy. Three anchor-based methods were used to examine the MIC: the ROC-based method (MIC
Result: MIC
Conclusions: Our data provide the first estimate of MIC value for the Chinese WAB-AQ. Future studies with larger sample sizes are needed to refine the estimated value.
Clinical Rehabilitation Impact: The current study has advanced the research on the properties of Chinese WAB.
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http://dx.doi.org/10.23736/S1973-9087.25.08657-5 | DOI Listing |
Eur J Phys Rehabil Med
March 2025
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China -
Background: There is limited research on the Minimal Important Change (MIC) of the Chinese Western Aphasia Battery (WAB). Since an MIC for Chinese WAB has yet to be established, the clinical implications of data using the Chinese WAB remain unclear.
Aim: This study was to establish the MIC of the Aphasia Quotient (AQ) of the Chinese WAB.
Bioorg Chem
March 2025
State Key Laboratory Base of Eco-chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.. Electronic address:
In this study, 30 tilmicosin-hydrazone derivatives were designed using MOE software. Six candidate molecules with strong binding affinity to DNA or DNA-Topo II complexes, as indicated by molecular docking results, were synthesized. These candidates were evaluated for their in vitro antibacterial activities against common Gram-positive and Gram-negative bacteria.
View Article and Find Full Text PDFEur J Med Chem
March 2025
School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China; BayRay Innovation Center, Shenzhen Bay Laboratory, Shenzhen, 518132, PR China. Electronic address:
Vancomycin is primarily used to treat severe infections caused by Gram-positive bacteria and is often considered as the last-resort therapy in the life-threatening situation. However, it is inherently ineffective against Gram-negative bacteria. Herein, we report the design, synthesis, and biological evaluation of novel vancomycin analogues incorporated with lipophilic cationic groups.
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CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People's Republic of China.
Targeting drug-resistant Acinetobacter baumannii, two fungal strains, Epicoccum sp. 1-042 and Penicillium sp. 19-115, were identified from 35 fungi isolated from Tibet.
View Article and Find Full Text PDFJ Ethnopharmacol
March 2025
Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518000, PR China. Electronic address:
Ethnopharmacological Relevance: Terminalia bellirica (Gaertn.) Roxb. (Combretaceae) (T.
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