AI Article Synopsis
- The study aimed to explore how plasma α-synuclein levels relate to cerebral blood flow in Parkinson's disease patients who experience freezing of gait (FOG).
- A total of 120 Parkinson's patients were assessed for FOG and divided into two groups: those with FOG and those without.
- Results showed that patients with FOG had slower blood flow in key arteries and higher α-synuclein levels, indicating that these factors independently increase the risk of FOG in Parkinson's disease.
Article Abstract
Background: The aim of this study was to investigate the relationship between plasma α-synuclein (α-syn) levels and cerebral blood flow in patients with Parkinson disease (PD) with freezing of gait (FOG).
Methods: A total of 120 cases of PD patients were selected, and FOG was evaluated according to the FOG questionnaire, with a score of > 3 classified as FOG. Based on the evaluation results, the patients were divided into the PD-FOG group (58 cases) and the PD-NFOG group (62 cases). Cerebral blood flow parameters including cerebral blood flow velocity (CBFV) of the middle cerebral artery, posterior cerebral artery, and basilar artery, phase difference, and gain were monitored, and plasma α-syn levels were measured by enzyme-linked immunosorbent assay. Multifactorial logistic regression analysis was performed to explore the influencing factors of patients with Parkinson's with FOG.
Results: FOG occurred in 58 out of 120 cases of PD patients, and the prevalence rate amounted to 48.3%. CBFV of the middle cerebral artery, posterior cerebral artery, and basilar artery were slower, phase difference was smaller, and plasma α-syn level was higher in the PD-FOG group. CBFV of the middle cerebral artery, posterior cerebral artery, and basilar artery, phase difference, and plasma α-syn level were independent influences on FOG in PD patients.
Conclusions: Decreased cerebrovascular reserve function and increased plasma α-synuclein level increase the risk of FOG in PD patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7754/Clin.Lab.2024.240756 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Superficial Temporal Artery-Middle Cerebral Artery Bypass Treatment Planning for Cerebral Ischaemia Based on Multi-Scale Model.
Int J Numer Method Biomed Eng
March 2025
College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Superficial temporal artery and middle cerebral artery (STA-MCA) bypass surgery is an effective method to enhance cerebral blood flow (CBF) in ischemic patients. However, the effectiveness of various bypass techniques varies with the diversity of Circle of Willis (CoW) structures. This study aims to develop a physiologically realistic hemodynamic model to optimize STA-MCA bypass planning for cerebral ischemia patients with different CoW structures.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore how plasma α-synuclein levels relate to cerebral blood flow in Parkinson's disease patients who experience freezing of gait (FOG).
- A total of 120 Parkinson's patients were assessed for FOG and divided into two groups: those with FOG and those without.
- Results showed that patients with FOG had slower blood flow in key arteries and higher α-synuclein levels, indicating that these factors independently increase the risk of FOG in Parkinson's disease.
Angioinvasive Mucormycosis and Internal Carotid Artery Thrombosis: A Case Series.
Indian J Otolaryngol Head Neck Surg
January 2025
Otolaryngology - Head and Neck Surgery, Patna Medical College, Patna, Bihar India.
Rhinocerebral mucormycosis is an acute, rapidly progressing, and life-threatening condition that predominantly affects individuals with uncontrolled diabetes and those who are immunocompromised. One critical complication of this disease is the thrombosis of orbital vessels, which can be indicative of angioinvasiveness and predict the subsequent development of cerebral infarctions. In this context, we present a case series of patients with rhino-orbital mucormycosis who experienced complications due to internal carotid artery thrombosis.
View Article and Find Full Text PDFPulmonary Artery Denervation for Medication Refractory Pulmonary Hypertension (PARPH Study) - Study Protocol for a Prospective, Open-Label, Single-Arm Clinical Trial.
Circ Rep
March 2025
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Osaka Japan.
Background: Despite the development of effective pulmonary vasodilators, the prognosis for patients with pulmonary hypertension (PH) remains poor, particularly in medication-refractory patients. Catheter-based pulmonary artery denervation (PADN) is an emerging therapeutic strategy targeting the sympathetic nervous system in various types of PH. However, data on its safety and efficacy in refractory patients with PH who truly require non-pharmacotherapy are lacking.
View Article and Find Full Text PDFEndoscopic Hematoma Evacuation for Spontaneous Acute Subdural Hematoma: The Role of Preoperative Imaging.
Cureus
February 2025
Department of Neurosurgery, International University of Health and Welfare Narita Hospital, Narita, JPN.
Spontaneous acute subdural hematoma (SDH) is a rare but potentially life-threatening condition. We present the case of a 73-year-old man with spontaneous acute SDH in which a computed tomography angiography (CTA) demonstrated contrast extravasation from a cortical artery. The patient was successfully treated with endoscopic hematoma evacuation via a small craniotomy, minimizing surgical invasiveness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!