Background: The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital.
Methods: The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials. Patient plasma samples were used to compare results of coagulation measurements between the Sysmex CN-6000 and the Atellica COAG 360, including plasma samples with visual interference. The sample throughputs of both analyzers were compared using plasma samples from healthy volunteers.
Results: Within- and between-day coefficients of variation were acceptable for all assays tested on the Sysmex CN-6000. High correlation and good agreement were observed when comparing coagulation results from the Sysmex CN-6000 and the Atellica COAG 360. Samples with visual interference showed comparable coagulation results between the two analyzers, with slightly better detection by the Sysmex CN-6000. The sample throughput per hour for analysis of a panel of five coagulation parameters was higher with the Sysmex CN-6000 compared to the Atellica COAG 360 (247 vs. 193 tests).
Conclusions: The Sysmex CN-6000 demonstrated excellent analytical performance for a large number of coagulation parameters and has a high throughput capacity, ideal for the needs of a central laboratory with a high volume of routine and specialized coagulation testing.
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| http://dx.doi.org/10.7754/Clin.Lab.2024.240922 | DOI Listing |
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Background: The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital.
Methods: The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials.
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March 2025
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
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Methods Mol Biol
May 2023
Sysmex America Inc., Lincolnshire, IL, USA.
Light transmission aggregometry (LTA) has long been the historical "gold standard" of platelet function testing and is typically performed in specialized hemostasis laboratories due to its manual and labor intensive process. However, newer automated testing provides a means of standardization and ability to perform the testing in routine laboratories. Here we describe the measurement of platelet aggregation in the CS-Series (Sysmex Corporation, Kobe, Japan) and CN-Series™ (Sysmex Corporation, Kobe, Japan) routine blood coagulation analyzers.
View Article and Find Full Text PDFPerformance evaluation of the Sysmex CN-6000-automated coagulation analyzers for routine coagulation tests.
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Department of Laboratory Medicine, Pusan National University School of Medicine.
The Sysmex CN-6000 is a novel automated multiparameter coagulometer that performs clotting, chromogenic and immunological assays, and platelet aggregation tests in a single system. Here we evaluated its performance of routine coagulation assays. The precision, linearity, carryover and establishment of reference ranges of the CN-6000, as well as correlations between it and the currently used Diagnostica Stago STA-R Max were determined according to Clinical and Laboratory Standards Institute guidelines.
View Article and Find Full Text PDFPerformance evaluation of the fully automated random-access multiparameter Sysmex CN-6000 hemostasis analyzer at a core laboratory with a high sample throughput.
Int J Lab Hematol
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Assistance Publique Hôpitaux de Paris, Department of Haematology, Pitié-Salpêtrière Hospital, Paris, France.
Introduction: We aimed to evaluate the performance of the fully automated multiparameter CN-6000 hemostasis analyzer.
Methods: Performance evaluation of the CN-6000 analyzer was conducted for 10 tests including prothrombin time (PT), activated partial prothrombin time (aPTT), fibrinogen level, anti-Xa activity, and antithrombin activity using a unique portfolio of liquid ready-to-use reagents. Precision, sample and reagent carryovers, throughput, and sample turnaround time (STAT) function were prospectively assessed.
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