Designing nanoparticles to minimize unintended inflammatory responses: a step toward safer and more effective precision nanomedicine.

Nanomedicine (Lond)

Laboratory of Inflammation and Vaccines, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, P.R. China.

Published: March 2025

Download full-text PDF

Source
http://dx.doi.org/10.1080/17435889.2025.2476377DOI Listing

Publication Analysis

Top Keywords

designing nanoparticles
4
nanoparticles minimize
4
minimize unintended
4
unintended inflammatory
4
inflammatory responses
4
responses step
4
step safer
4
safer effective
4
effective precision
4
precision nanomedicine
4

Similar Publications

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.

View Article and Find Full Text PDF

Hybrid multicompartment artificial architectures, inherited from different compartmental systems, possess separate microenvironments that can perform different functions. Herein, a hybrid compartmentalized architecture via hybridizing ferritin nanocage (Fn) with non-aqueous droplets using aminated-modified amphiphilic gelatin (AGEL) is proposed, which enables the generation of compartmentalized emulsions with hybrid multicompartments. The resulting compartmentalized emulsions are termed "hybrasome".

View Article and Find Full Text PDF

Acute myocardial infarction, a leading cause of death globally, is often associated with cardiometabolic disorders such as atherosclerosis and metabolic syndrome. Metabolic treatment of these disorders can improve cardiac outcomes, as exemplified by the GLP-1 agonist semaglutide. Fibroblast growth factor 21 (FGF21), a novel metabolic regulator, plays pivotal roles in lipid mobilization and energy conversion, reducing lipotoxicity, inflammation, mitochondrial health, and subsequent tissue damage in organs such as the liver, pancreas, and heart.

View Article and Find Full Text PDF

FeCo: Hysteresis, Pseudo-Critical, and Compensation Temperatures on Quasi-Spherical Nanoparticle.

Nanomaterials (Basel)

February 2025

Facultad de Ciencias Básicas, Departamento de Física y Electrónica, Universidad de Córdoba, Monteria 230002, Colombia.

We investigated the hysteresis, pseudo-critical, and compensation behaviors of a quasi-spherical FeCo alloy nanoparticle (2 nm in diameter) using Monte Carlo simulations with thermal bath-type algorithms and a 3D mixed Ising model. The nanostructure was modeled in a body-centered cubic lattice (BCC) through the following configurations: spin S=3/2 for Co and Q=2 for Fe. These simulations reveal that, under the influence of crystal and magnetic fields, the nanoparticle exhibits compensation phenomena, exchange bias, and pseudo-critical temperatures.

View Article and Find Full Text PDF

A new delivery system was designed and synthesized to increase the efficiency of Docetaxel. For this aim, γ-Fe2O3 was synthesized in order to give the nanoparticle the ability to be magnetic targeted. It was functionalized with citric acid to prevent clumping and maintain stability.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!