A Retroprospective observational study was conducted on Covid-19-associated mucormycosis (CAM) patients who underwent surgery at our institute. A total of 175 patients who met the inclusion and exclusion criteria were included in our study The study aimed to correlate the Overall survival and disease-specific survival rates with sites of involvement in patients with Covid Associated Mucormycosis and develop a novel prognostic classification of Mucormycosis. At the end of 24 months, the overall survival rate was 73.1% which can be attributed to the early diagnosis, timely & aggressive intervention, and multidisciplinary management. The Disease-Specific Survival rates were 90.16% (55alive/61total) for Sinonasal Mucormycosis, 87% (41/47) for Rhinomaxillary Mucormycosis, 64.7% (22/34) for Rhinoorbital Mucormycosis and 45.45% (10/22) for Rhinocerebral Mucormycosis. A statistically significant difference was seen between the disease severity and outcome. a novel staging system was developed with a focus on long-term patient outcomes. ANPCRM tapers patients' expectations and provides an ordinal measure of treatment outcome. It allows triaging of patients and better allocation of resources based on the final outcome which is the chances of survival of the patients.
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http://dx.doi.org/10.1007/s12070-024-05210-9 | DOI Listing |
Front Immunol
March 2025
Department of Digestive Endoscopy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Background: Esophageal squamous cell carcinoma (ESCC) represents a frequent cancer with a poor prognosis. Altered glucose metabolism contributes factor to ESCC progression. In our previous study, signal sequence receptor subunit delta (SSR4) was included in an ESCC prognostic model; however, the mechanisms underlying SSR4 implication in ESCC remain ambiguous.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Department of Dermatology, All India Institute of Medical Sciences, Raipur, India.
A Retroprospective observational study was conducted on Covid-19-associated mucormycosis (CAM) patients who underwent surgery at our institute. A total of 175 patients who met the inclusion and exclusion criteria were included in our study The study aimed to correlate the Overall survival and disease-specific survival rates with sites of involvement in patients with Covid Associated Mucormycosis and develop a novel prognostic classification of Mucormycosis. At the end of 24 months, the overall survival rate was 73.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
February 2025
Sri Ramachandra Medical College and Hospital, Chennai, Tamil Nadu India.
The aim of the study is to assess and correlate the stage of cholesteatoma with its surgical outcome using the ChOLE classification, and thus revalidate it. Study Design: This was a prospective, observational study conducted in the Department of ENT, Head and Neck Surgery at SRIHER from Dec 2020 to Dec 2022. Sample Size: A total of 73 patients with acquired cholesteatoma.
View Article and Find Full Text PDFOncologist
March 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, People's Republic of China.
NK-large granular lymphocytic leukemia (NK-LGLL) is a rare chronic lymphoproliferative disorder and displays heterogeneity that remains insufficiently defined. CD56 plays a pivotal role in NK-cell maturation linked to cytotoxicity. However, whether CD56 might be associated with distinctive characteristics in NK-LGLL has not been determined.
View Article and Find Full Text PDFArch Gynecol Obstet
March 2025
Department of Obstetrics and Gynecology, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang, 050011, China.
Purpose: Endometrial carcinoma (EC) represents the most prevalent malignancy of the female genital tract in the United States, with lymphovascular space invasion (LVSI) recognized as a critical prognostic factor that significantly influences disease outcomes. This review aims to elucidate the evolving understanding of LVSI in early-stage EC, highlighting its implications for stratification, quantification, and clinical management.
Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
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