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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891520 | PMC |
| http://dx.doi.org/10.1136/tsaco-2025-001792 | DOI Listing |
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Is hyponatremia after geriatric trauma the new frailty?
Trauma Surg Acute Care Open
March 2025
Department of Surgery, University of San Francisco, San Francisco, California, USA.
Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database.
Therapie
February 2025
Pharmacology Department, CHU de Caen, 14000 Caen, France; Psychiatric Department, CHU de Caen, 14000 Caen, France.
Objectives: The objective is to investigate the association between antidepressant drugs intake and falls reporting, as well as the potential mediators in-between, in older adults.
Methods: In VigiBase®, the World Health Organization's pharmacovigilance database, we performed a disproportionality analysis to probe the putative associations between each antidepressant drugs class (non-selective monoamine reuptake inhibitors [NSMRIs], selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs], alpha-2-adrenergic receptor antagonists, and "other antidepressants") and reports of falls in people aged 65 and over (NCT05628467). The reporting odds ratios and their 95% confidence interval were derived from logistic regression models with adjustment for confounders.
Evaluation of hyponatremia among older adults exposed to selective serotonin reuptake inhibitors and thiazide diuretics.
Pharmacotherapy
March 2025
Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.
Objective: Hyponatremia is a common electrolyte disorder among older adults that can cause serious adverse effects. The purpose of this study was to assess the risk of hyponatremia with the concurrent use of selective serotonin reuptake inhibitors (SSRIs) and thiazide diuretics in an older population.
Methods: Two retrospective nested case-control studies were conducted with exposure to an SSRI or a thiazide diuretic.
Over-supplement of vitamin D may cause delirium, abdominal distension, and muscle weakness in the elderly: A case report and literature review.
Medicine (Baltimore)
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Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
Rationale: Vitamin D deficiency is common among the elderly due to limited sunlight exposure, increasing osteoporosis risk. Over-supplementation poses risks, especially with caregiver involvement.
Patient Concerns: Rising vitamin D overdose cases underscore the need for better education on safe intake and monitoring practices to prevent toxicity, particularly hypercalcemia from excessive doses.
Association of hyponatremia with outcomes after geriatric trauma: a systematic review and meta-analysis.
Trauma Surg Acute Care Open
February 2025
Division of Acute and Critical Care Surgery, Department of Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Background: Trauma is a major cause of mortality in the elderly population. Hyponatremia is the most common electrolyte imbalance in geriatric patients and has been demonstrated to be a risk factor for altered cognition, low bone density, falls, and death. We systematically and critically reviewed the literature to ascertain the association between hyponatremia and geriatric trauma outcomes.
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