The emerging fungal pathogen () has been increasingly detected in environmental and animal samples, although studies in this regard are still scarce, especially in fisheries contexts. This study reports the first-time detection of in a commercially relevant fish species belonging to the Sciaenidae family ( sp.), indicating its potential emergence as a pathogen in Brazil. We applied CHROMagar Candida Plus medium identification associated to Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) for the identification of isolates. Although only one fish specimen was shown to be contaminated by , this study provides the first evidence of this yeast circulating in commercially relevant fish species in Brazil, highlighting the potential risks associated with this emerging pathogen.
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http://dx.doi.org/10.3389/ffunb.2025.1545572 | DOI Listing |
Front Immunol
March 2025
Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
T-regulatory-type-1 (TR1) cells are a subset of interleukin-10-producing but Foxp3 Treg cells that arise in response to chronic antigenic stimulation. We have shown that systemic delivery of autoimmune disease-relevant peptide-major histocompatibility complex class II (pMHCII)-coated nanoparticles (pMHCII-NP) triggers the formation of large pools of disease-suppressing Foxp3 TR1 cells from cognate T-follicular helper (TFH) cell precursors. Here we show that, upon treatment withdrawal, these Foxp3 TR1 cells spontaneously differentiate into a novel immunoregulatory Foxp3 TR1 subset that inherits epigenetic and transcriptional hallmarks of their precursors, including clonotypic T-cell receptors, and is distinct from other Foxp3 Treg subsets.
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Naval Medical University (Changhai Hospital of Shanghai), Shanghai, China.
Immunotherapy has brought better survival benefits in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, owing to the lack of relevant biomarkers that could predict the efficacy of this treatment, it often has to be maintained. Here we report on a patient with stage IVA squamous cell carcinoma of the tongue who developed an unresectable lesion in the neck after surgery and radical chemoradiotherapy.
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March 2025
Department of Digestive Endoscopy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Background: Esophageal squamous cell carcinoma (ESCC) represents a frequent cancer with a poor prognosis. Altered glucose metabolism contributes factor to ESCC progression. In our previous study, signal sequence receptor subunit delta (SSR4) was included in an ESCC prognostic model; however, the mechanisms underlying SSR4 implication in ESCC remain ambiguous.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Basaveshwara Medical College & Hospital, Chitradurga, Karnataka 577501 India.
Sublingual epidermoid cysts are rare benign lesions derived from ectodermal tissue, typically located beneath the tongue or the floor of the mouth. While often asymptomatic, these cysts can grow and cause discomfort or complications, making accurate diagnosis and appropriate treatment crucial. We present the case of a 6-year-old Indian girl diagnosed with an implantation keratinized sublingual epidermoid cyst, initially misidentified as a plunging ranula.
View Article and Find Full Text PDFFront Fungal Biol
February 2025
Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
The emerging fungal pathogen () has been increasingly detected in environmental and animal samples, although studies in this regard are still scarce, especially in fisheries contexts. This study reports the first-time detection of in a commercially relevant fish species belonging to the Sciaenidae family ( sp.), indicating its potential emergence as a pathogen in Brazil.
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