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http://dx.doi.org/10.1093/ehjcr/ytaf096 | DOI Listing |
J Crohns Colitis
March 2025
Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.
Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.
Front Immunol
March 2025
Division of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
High tumour mutational burden (TMB-high), identified through comprehensive genomic profiling (CGP), is a biomarker that predicts the efficacy of immune checkpoint inhibitors. CGP testing is recommended for rare cancers with limited effective treatment options. Here, we provide the first report of a malignant phyllodes tumour of the breast demonstrating TMB-high status and effective treatment with pembrolizumab.
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March 2025
Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Naval Medical University (Changhai Hospital of Shanghai), Shanghai, China.
Immunotherapy has brought better survival benefits in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, owing to the lack of relevant biomarkers that could predict the efficacy of this treatment, it often has to be maintained. Here we report on a patient with stage IVA squamous cell carcinoma of the tongue who developed an unresectable lesion in the neck after surgery and radical chemoradiotherapy.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Trustwell Hospital, Banglore, India.
Lipomas are benign tumours composed of adipose tissue which are rare in paediatric age group, all the more infrequent over head and neck region. We report a case of 15 month old male child who presented with a history of swelling over the left side of the face for the duration and months. Patient was initially operated at 5 months of age elsewhere and presented to us with recurrence of the swelling at 15 months of age.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Department of ENT, Choithram Hospital and Research Center, Flat 902, Block A3, Avasa Housing, Opp Phalbag, Main AB Road, Indore, Madhya Pradesh 452012 India.
Thyroglossal duct cysts are the most common form of congenital neck cysts. The incidence of thyroid papillary carcinoma in thyroglossal duct cyst is less than 1%. In most cases, the diagnosis is made postoperatively.
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