Medicinal plants are crucial in the comprehensive treatment of anti-tumor with the advantages of high efficacy, low toxicity, multiple pathways and multi-targets synergy, leading to be a focal point of study for many oncologists. Identifying effective monomer components with anti-tumor properties from medicinal plants has long been a crucial focus in the study and development of traditional Chinese medicine. This endeavor has significant research value and promising possibilities for further advancement. Asiatic Acid (AA), a pentacyclic triterpenoid derived from (L.) Urb, is used in traditional Chinese medicine and has been shown to have anti-tumor properties on a range of tumor types. The present study assessed the anti-tumor properties of AA from five different perspectives: inhibiting proliferation, inducing apoptosis, inhibiting invasion and metastasis, regulating cell autophagy, enhancing the resistance of tumor cells to drugs, and minimizing adverse side effects.
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http://dx.doi.org/10.3389/fphar.2025.1545654 | DOI Listing |
Front Bioeng Biotechnol
February 2025
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Head and neck squamous cell carcinoma (HNSCC) frequently invades the jaw, and surgical treatment often leads to bone defects requiring reconstruction with titanium plates. To enhance the anti-tumor and bone regeneration properties of titanium, a selenium-modified hydroxyapatite coating was developed on titanium surfaces.
Methods: Selenium-modified hydroxyapatite coatings was fabricated using micro-arc oxidation (MAO).
Front Pharmacol
February 2025
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Medicinal plants are crucial in the comprehensive treatment of anti-tumor with the advantages of high efficacy, low toxicity, multiple pathways and multi-targets synergy, leading to be a focal point of study for many oncologists. Identifying effective monomer components with anti-tumor properties from medicinal plants has long been a crucial focus in the study and development of traditional Chinese medicine. This endeavor has significant research value and promising possibilities for further advancement.
View Article and Find Full Text PDFInt J Nanomedicine
March 2025
Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
In recent years, nanobiotechnology, widely used in hepatoma, holds great promise for improving targeted hepatocarcinoma therapy. On account of the unique properties of low toxicity, good tolerance, biocompatibility, and biodegradability of new nanomaterials, a targeted drug delivery system (TDDS) has been constructed, which can boost the therapeutic effect of hepatoma-targeted drugs, reduce drug toxicity, and minimize off target reactions by enhancing permeability retention effect (EPR) and active targeting, thus improving existing liver cancer targeted therapy strategies. Different nanoparticles have their own advantages and disadvantages.
View Article and Find Full Text PDFJ Tradit Complement Med
March 2025
Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, PR China.
Atractylenolide III, a sesquiterpene extracted from the rhizome of Atractylodes macrocephala (Asteraceae), exhibits pharmacological effects, including improvement of gastrointestinal function, regulation of immune function, anti-inflammatory and antibacterial properties. Pyrotinib, a representative TKI originally developed in China, is classified as a Class 1.1 novel drug, exhibits superior efficacy compared to similar drugs.
View Article and Find Full Text PDFFood Chem
March 2025
The Department of Stomatology, The Second Affiliated Hospital of Air Force Medical University, No.569 Xinsi Road, Xi'an 710038, Shaanxi, China. Electronic address:
Rubus L. is widely distributed throughout the world as a medicinal and food plant with rich values. There is increasing evidence that Rubus L.
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