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| http://dx.doi.org/10.3389/fcell.2025.1558476 | DOI Listing |
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Ferroptosis and cuproptosis in periodontitis: recent biological insights and therapeutic advances.
Front Immunol
March 2025
Department of Endodontics, Southern Medical University Stomatological Hospital, Guangzhou, China.
Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research and clinical attention. Although ferroptosis and cuproptosis have emerged as significant areas of research in the medical field, their precise roles in the pathogenesis of periodontitis remain unclear. We aim to systematically summarize the current research on ferroptosis and cuproptosis in periodontal disease and investigate the roles of glutathione pathway and autophagy pathway in connecting ferroptosis and cuproptosis during periodontitis.
View Article and Find Full Text PDFRobotic animals as new tools in rodent neuroscience research: proposed applications of zooinspired robots for mouse behavioral testing.
Front Behav Neurosci
February 2025
Institute of Experimental Neurology (INSPE), Division of Neuroscience (DNS), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Bioinspired robots are machines which reproduce structural or functional features of a living organism. In particular, the bioinspired robots which reproduce features of animals can be more specifically defined as zooinspired robots. Currently, the applications of animal robots are various and range across different fields, such as, for instance, nature conservation, search and rescue of humans after natural or man-made disasters, exploration of extraterrestrial environments and robotic pets for elderly people under care for dementia.
View Article and Find Full Text PDFPregnancy and pulmonary artery hypertension: Management challenges.
Int J Cardiol Congenit Heart Dis
March 2025
Department of Obstetrics, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Pulmonary hypertension (PH) is a term used to describe a complex heterogenous group of conditions defined by a mean pulmonary arterial pressure of more than 20 mmHg at rest on right-heart catheterization. PH in pregnancy is associated with high rates of maternal morbidity and mortality and poor fetal outcomes. Currently, pregnancy in these women is classified as modified WHO class IV (pregnancy contraindicated).
View Article and Find Full Text PDFoncology: a mechanistic multiscale model of clinical prostate cancer response to external radiation therapy as the core of a digital (virtual) twin. Sensitivity analysis and a clinical adaptation approach.
Front Physiol
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German Cancer Consortium (DKTK), Partner Site Freiburg, Heidelberg, Germany.
Introduction: Prostate cancer (PCa) is the most frequent diagnosed malignancy in male patients in Europe and radiation therapy (RT) is a main treatment option. However, current RT concepts for PCa have an imminent need to be rectified in order to modify the radiotherapeutic strategy by considering (i) the personal PCa biology in terms of radio resistance and (ii) the individual preferences of each patient.
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Wayne State University, Detroit, MI, United States.
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