Introduction: Richter's transformation (RT) from chronic lymphocytic leukemia (CLL) to lymphoma carries poor prognosis. This case series examines the efficacy of lisocabtagene maraleucel (liso-cel) in six RT patients, highlighting the impact of concurrent ibrutinib therapy.
Methods: Six patients were with RT who received liso-cel from were included in this single institution case series. Clinical data related to efficacy, safety, CAR-T expansion kinetics, and measurable residual disease were collected.
Results: The best overall response was 83.3%. The four patients who received ibrutinib concurrent with liso-cel therapy continue to show MRD-negative complete response till date. None experienced severe (grade 3+) cytokine release syndrome while 1 had severe (grade 3+) immune-effector cell-associated neurotoxicity syndrome (ICANS). All patients were noted to have in vivo CAR expansion.
Conclusion: This series of real cases suggests liso-cel with concurrent ibrutinib may be a promising treatment for RT, warranting further exploration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891774 | PMC |
| http://dx.doi.org/10.1002/jha2.70011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis.
J Crohns Colitis
March 2025
Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.
Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.
Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection.
Front Immunol
March 2025
Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
This case series reports three patients initially managed for presumed infectious meningoencephalitis, who were ultimately diagnosed with myelin oligodendrocyte glycoprotein associated disease (MOGAD). Their clinical presentations were strikingly similar to those of acute infectious meningoencephalitis, which posed a challenge to the initial diagnostic process. Notably, despite the absence of typical radiological changes associated with MOGAD, such as cerebral cortical encephalitis, these patients exhibited focal neurological and electroencephalographic changes.
View Article and Find Full Text PDFAngioinvasive Mucormycosis and Internal Carotid Artery Thrombosis: A Case Series.
Indian J Otolaryngol Head Neck Surg
January 2025
Otolaryngology - Head and Neck Surgery, Patna Medical College, Patna, Bihar India.
Rhinocerebral mucormycosis is an acute, rapidly progressing, and life-threatening condition that predominantly affects individuals with uncontrolled diabetes and those who are immunocompromised. One critical complication of this disease is the thrombosis of orbital vessels, which can be indicative of angioinvasiveness and predict the subsequent development of cerebral infarctions. In this context, we present a case series of patients with rhino-orbital mucormycosis who experienced complications due to internal carotid artery thrombosis.
View Article and Find Full Text PDFPredictive factors for visual prognosis in neurosyphilis presenting with optic atrophy: a Chinese case series study.
Front Neurol
February 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Background: We aimed to explore the clinical features and predictive factors for visual prognosis of neurosyphilis-associated optic atrophy (NSAOA).
Methods: This retrospective observational study included 17 patients (33 eyes) with NSAOA who received standard anti-ocular syphilis treatment. LogMAR (logarithm of the minimum angle of resolution) best-corrected visual acuity (BCVA), visual field, and optical coherence tomography, were recorded at baseline, short-term (within one month after treatment), and long-term (> 6 months) follow-up.
Late pandemic COVID-19 positivity at the time of thrombectomy is associated with poor outcomes and tandem carotid pathology.
Front Neurol
February 2025
Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, United States.
Objectives: COVID-19 is an independent risk factor for ischemic stroke. Studies from early in the pandemic show increased rates of unfavorable recanalization, poor outcomes, and mortality in patients who were COVID-19 positive at the time of mechanical thrombectomy. However, there are currently no studies examining these parameters during the later pandemic when circulating variants were less virulent.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!