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http://dx.doi.org/10.5812/ijpr-156667 | DOI Listing |
Iran J Pharm Res
December 2024
Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Pharm Pharmacol
October 1992
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
The preparation of some tropane analogues of pethidine and its reversed ester, chiefly with preferred 3 alpha-m-hydroxyphenyl chair conformations, is described. The former were secured from tropan-3-one in a sequence of reactions involving cyanide attack, hydrolysis, Grignard attack and then rearrangements. The reversed ester was obtained by treating tropan-3-one with lithium phenyl, followed by acylation.
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