Primary hyperparathyroidism is an endocrine disorder with muti-system involvement. The clinical condition is dealt by multi-speciality department. Parathyroid adenoma is the principal cause of primary hyperparathyroidism. Parathyroid neoplasm is a spectrum disorder and has been classified into following: Parathyroid hyperplasia, parathyroid adenoma and parathyroid carcinoma. Hypercalcemia and raised parathormone are characteristic determinants of primary hyperparathyroidism. According to literature, a giant parathyroid adenoma is defined as one weighing more than 3.5 g. To the best of our knowledge, this first case report in south asia presenting as cervical swelling with stridor. Giant parathyroid adenoma weighed 184 g in our patient. Rise in parathyroid hormone level leads to variable systemic symptoms primarily due to hypercalcemia. Constipation, fatigue, weakness, recurrent episodes of renal stones, brown tumors are some of common systemic manifestation. We present a case report of 56 years female with cervical swelling and breathing difficulty at presentation.
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http://dx.doi.org/10.1007/s12070-024-05261-y | DOI Listing |
Indian J Otolaryngol Head Neck Surg
February 2025
Department of General Surgery, Amrita Institute of Medical Sciences, Amrita Hospitals, Kochi, Kerala India.
Despite the popularity of auto analyzers in urban areas of the country the incidence of asymptomatic hyperparathyroidism has not markedly increased and symptomatic diseases are regularly seen in all major institutions. The present single-institution analysis of proven hyperparathyroidism in the last 16 years was aimed at comparing the demographic, clinical, and pathological characteristics of symptomatic and asymptomatic primary hyperparathyroidism and comparing those with the asymptomatic diseases seen in developed countries. A retrospective chart review of 332 patients was done and 29 (8.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Objective: To assess the impact of parathyroid gland (PG) classification on hypoparathyroidism incidence following total thyroidectomy (TT) with central neck dissection (CND) in patients with differentiated thyroid carcinoma (DTC).
Methods: In this prospective cohort study, adult patients with DTC who underwent TT with CND between 2021 and 2023 were enrolled, with a maximum follow-up duration of 32 months. A simplified PG classification system was employed, categorizing glands into four distinct types: tightly connected, loosely connected, non-connected, and thymic.
Indian J Otolaryngol Head Neck Surg
February 2025
AIIMS Bathinda Punjab, Bathinda, 151001 India.
Primary hyperparathyroidism is an endocrine disorder with muti-system involvement. The clinical condition is dealt by multi-speciality department. Parathyroid adenoma is the principal cause of primary hyperparathyroidism.
View Article and Find Full Text PDFClin Nucl Med
March 2025
Department of Nuclear Medicine, Imaging Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
A 46-year-old woman with primary hyperparathyroidism and negative sestamibi parathyroid scan was referred for 18F-fluorocholine (18F-FCH) positron emission tomography (PET/CT) scan to help localize parathyroid adenoma. FCH PET/CT scan identified a hyperfunctioning parathyroid gland in the left neck. In addition, there was unusually intense unilateral FCH uptake in the right breast corresponding to dense soft tissue.
View Article and Find Full Text PDFEctopic mediastinal parathyroid adenoma is rare and is generally managed by surgical resection as a definitive treatment. Intraoperative parathyroid hormone (ioPTH) monitoring is valuable for ensuring the complete removal of a target lesion. However, there is no consensus criteria regarding the utilization of ioPTH for complete resection in patients with ectopic mediastinal parathyroid adenomas.
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