Dedifferentiated liposarcoma (DDLPS) is a nonlipogenic sarcoma arising in association with well-differentiated liposarcoma (LPS), and represents 10% of liposarcomas. Most of the cases of dedifferentiated liposarcoma arise in the retroperitoneal region, followed by deep soft tissue of the extremities, trunk, mediastinum, spermatic cord, and the head and neck region. We report a case of a 35 year old male patient who had DDLPS of the left parotid gland.
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http://dx.doi.org/10.1007/s12070-024-05239-w | DOI Listing |
ANZ J Surg
March 2025
Division of Cancer Surgery, Peter MacCallum Cancer Centre, and Sir Peter MaCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Purpose: Retroperitoneal sarcomas (RPS) present a surgical challenge due to their complex anatomical relationships to organs and vascular structures. In this limited case series, we reconstructed the tumour beds of four cases of RPS and their ex vivo specimens.
Methods: Four patients underwent surgical resection of their retroperitoneal sarcoma at our centre in 2023-2024.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Pathology, Dr. D.Y. Patil Medical College and Research Institute, Kolhapur, Maharashtra India.
Hibernomas are infrequent brown adipose tissue neoplasms. The thighs, shoulder, neck, and back are the most common places they appear. These are benign lipomatous neoplasms.
View Article and Find Full Text PDFBackground: Soft tissue sarcomas (STS) are rare, heterogeneous neoplasms often not optimally managed by teams without sarcoma expertise. Between 40 % and 50 % of primary resections for extremity sarcomas occur without prior biopsy, resulting in inadequate excisions, termed "unplanned resections" or "whoops surgery."
Objective: To determine the rate of unplanned resections in extremity STS referred to a high-volume sarcoma center and evaluate their impact on oncological outcomes.
Indian J Otolaryngol Head Neck Surg
February 2025
Oral and Maxillofacial Surgery, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha India.
Dedifferentiated liposarcoma (DDLPS) is a nonlipogenic sarcoma arising in association with well-differentiated liposarcoma (LPS), and represents 10% of liposarcomas. Most of the cases of dedifferentiated liposarcoma arise in the retroperitoneal region, followed by deep soft tissue of the extremities, trunk, mediastinum, spermatic cord, and the head and neck region. We report a case of a 35 year old male patient who had DDLPS of the left parotid gland.
View Article and Find Full Text PDFBr J Clin Pharmacol
March 2025
Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany.
Aims: Brigimadlin (BI 907828) is a potent, oral MDM2-p53 antagonist under clinical investigation for the treatment of advanced solid tumours. A brigimadlin exposure-tumour growth inhibition (E-TGI) model was developed to support the recommended phase II dose (RP2D) selection of brigimadlin in future clinical trials.
Methods: Population modelling was applied to analyse longitudinal tumour size (sum of longest diameters, SLD) data of 151 patients from a phase I trial treated with 5-80 mg brigimadlin every third or fourth week (q3w/q4w).
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