Urachal cystadenocarcinoma (UC) is a rare but highly aggressive subtype of bladder cancer. While most localized cases of UC are asymptomatic, occasionally, patients present with nonspecific lower urinary tract symptoms. Unfortunately, most cases are not detected until advanced disease is present. The presence of local nodal or distant metastasis is particularly important for prognosis, drastically reducing five-year overall survival rates. The gold standard for localized UC is wide surgical excision, with no established role of chemotherapy. On the contrary, endometrial carcinoma (EC) is the most common gynecologic malignancy. As such, staging, prognosis, and treatment guidelines of endometrial carcinoma are well-established. The gold standard treatment for localized endometrial carcinoma includes total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH-BSO) and lymph node dissection (LND). Concurrent cases of urachal cystadenocarcinoma and endometrial carcinoma are exceedingly rare. To the authors' knowledge, there have been no known reports of these co-occurring malignancies thus far in the literature. We present the case of a 66-year-old patient with nonspecific lower urinary symptoms and incidentally discovered UC in the setting of concurrent endometrial carcinoma. The patient underwent robotic excision of the urachal cystadenocarcinoma and TAH-BSO, followed by adjuvant chemotherapy and vaginal brachytherapy. Surveillance imaging at 16 weeks after surgery showed no evidence of disease recurrence.
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http://dx.doi.org/10.7759/cureus.78741 | DOI Listing |
Front Oncol
February 2025
Department of gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Introduction: Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.
View Article and Find Full Text PDFCureus
February 2025
Department of Urology, Rush University Medical Center, Chicago, USA.
Urachal cystadenocarcinoma (UC) is a rare but highly aggressive subtype of bladder cancer. While most localized cases of UC are asymptomatic, occasionally, patients present with nonspecific lower urinary tract symptoms. Unfortunately, most cases are not detected until advanced disease is present.
View Article and Find Full Text PDFAm J Med Sci
March 2025
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu Province, China. Electronic address:
Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies, with an annually increasing incidence and a poor prognosis. lncRNAs and microRNAs regulate the progression of UCEC through ceRNA networks. Additionally, m6A modification plays various roles in UCEC, and abnormal regulation of it can directly affect tumor progression.
View Article and Find Full Text PDFPLoS One
March 2025
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Ovarian cancer therapy remains a challenge for human health, partly due to chemotherapy resistance. Understanding the molecular mechanisms underlying this resistance is crucial. Therefore, to identify genes involved in cisplatin resistance in ovarian cancer, RNA-seq analysis of A2780cp (cisplatin-resistant) and A2780 (cisplatin-sensitive) cell lines was performed, revealing 1-acylglycerol-3-phosphate O-acyltransferase 3 (AGPAT3) as a differentially expressed candidate gene.
View Article and Find Full Text PDFArch Gynecol Obstet
March 2025
Department of Obstetrics and Gynecology, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang, 050011, China.
Purpose: Endometrial carcinoma (EC) represents the most prevalent malignancy of the female genital tract in the United States, with lymphovascular space invasion (LVSI) recognized as a critical prognostic factor that significantly influences disease outcomes. This review aims to elucidate the evolving understanding of LVSI in early-stage EC, highlighting its implications for stratification, quantification, and clinical management.
Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
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