We report the case of a 44-year-old male patient without a notable medical history who developed transient osteoporosis following surgery for a medial malleolus fracture, which led to a stress fracture and osteonecrosis, ultimately requiring total talar replacement. The patient sustained the fracture spraining his ankle while welding. Osteosynthesis was performed using two cannulated cancellous screws, whereas bone union was achieved 3.5 months postsurgery. Five months after surgery, ankle joint pain worsened without new trauma episodes. Magnetic resonance imaging (MRI) showed diffuse hyperintensity over the entire talus on short tau inversion recovery (STIR) sequences, whereas radiography and computed tomography (CT) revealed fracture lines in the posterior talus. The fracture was initially treated with a non-load-bearing period; however, compression progressed, thereby leading to a diagnosis of talar osteonecrosis and total talar replacement. One year postsurgery, the Japanese Society for Surgery of the Foot ankle-hindfoot scale score improved from 24 presurgery to 85. The patient is currently being followed up. The Hounsfield units (HU) of the talus at the time of the fragility fracture, retrospectively measured via CT, were lower in areas with fragility fractures than in those with medial malleolar fractures, which suggests osteoporotic changes in the talus. Pathology of the excised talus confirmed osteoporosis with thinning of the trabecular bone, which was consistent with the MRI findings and suggested that transient osteoporosis led to fragility fractures and talar necrosis. The findings suggest that the delayed diagnosis of transient osteoporosis led to fragility fractures and osteonecrosis. This case highlights the importance of considering transient talar osteoporosis as a differential diagnosis in cases of persistent pain after ankle fracture surgery and performing an MRI early to guide treatment.
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http://dx.doi.org/10.7759/cureus.78704 | DOI Listing |
Cureus
February 2025
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, JPN.
We report the case of a 44-year-old male patient without a notable medical history who developed transient osteoporosis following surgery for a medial malleolus fracture, which led to a stress fracture and osteonecrosis, ultimately requiring total talar replacement. The patient sustained the fracture spraining his ankle while welding. Osteosynthesis was performed using two cannulated cancellous screws, whereas bone union was achieved 3.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
March 2025
Bronchial asthma (asthma) is a common chronic respiratory disease. Standardized diagnosis, treatment and effective clinical management are critical to improving asthma control, improving patients' quality of life, and reducing the disease burden. Based on the latest evidence-based research from both domestic and international references, the Asthma Group of the Chinese Thoracic Society has revised the " ()".
View Article and Find Full Text PDFOrthopadie (Heidelb)
February 2025
Orthopädische Klinik des Centre Hospitalier de Luxembourg, Akademisches Lehrkrankenhaus der Universitätskliniken des Saarlandes, 78, rue d' Eich, 1460, Luxembourg, Luxemburg.
Background: The frequent use of magnetic resonance imaging (MRI) introduced "bone marrow edema" (BME) as a descriptive radiological term for hyperintense signal changes in fluid-sensitive sequences. With the optimization of MRI soft tissue contrast, BME has evolved into a valid prognostic indicator associated with pain genesis, trauma, mechanical overload, and progressive cartilage and joint destruction.
Diagnostics: Both osteonecrosis and BME manifest in early MRI as intraosseous fluid accumulation, characterized by hyperintense signals in T2-weighted and STIR sequences.
Int Urol Nephrol
January 2025
Nephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Introduction: Kidney transplantation is the preferred treatment for end-stage kidney disease (ESKD), enhancing survival and quality of life. However, kidney transplant recipients (KTRs) are at high risk for bone disorders, particularly low bone turnover disease, which increases fracture risk. Teriparatide, an anabolic agent, may provide a beneficial treatment option for these patients.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Endocrinology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Teriparatide (TPT) acts against severe primary (postmenopausal) osteoporosis (MOP), and it requires continuation with another anti-resorptive drug to conserve or enhance the effects on fracture risk reduction. To analyse the sequential pharmacotherapy in MOP who were treated upon a 24-month daily 20 µg TPT protocol (24-mo-TPT) followed by another 12 months of anti-resorptive drugs (12-mo-AR) amid real-life settings. 1.
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