Hepatitis B is a major health concern. It primarily affects the liver, but it can also cause systemic complications like antigenaemia and nephrotic syndrome. Nephrotic syndrome causes proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia and hypercoagulability. This hypercoagulable state may lead to a life-threatening complication of nephrotic syndrome: thromboembolism. This case report presents a rare medical case where a patient with chronic HBV develops nephrotic syndrome and subsequent pulmonary embolism. The co-occurrence of these diseases in a single patient highlights the importance of their intricate pathology. By examining this unique case, we aim to highlight the diagnostic and therapeutic challenges in such clinical presentations, providing valuable insight for professionals dealing with similar cases.
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http://dx.doi.org/10.1002/rcr2.70145 | DOI Listing |
Hepatitis B is a major health concern. It primarily affects the liver, but it can also cause systemic complications like antigenaemia and nephrotic syndrome. Nephrotic syndrome causes proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia and hypercoagulability.
View Article and Find Full Text PDFCommun Biol
March 2025
Department of Clinical Laboratory, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Membranous nephropathy (MN) is a primary glomerular disease commonly causing adult nephrotic syndrome. Characterized by thickened glomerular capillary walls due to immune complex deposition, MN is a complex autoimmune disorder. Its pathogenesis involves immune deposit formation, complement activation, and a heightened risk of renal failure.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
March 2025
School of Traditional Chinese Medicine, Shanghai University of Chinese Medicine, Shanghai, 201203, China.
Nephrotic syndrome (NS) is a common glomerular ailment caused by various factors and ranks as the second most frequently seen kidney disease. The study aims to investigate the potential therapeutic mechanism of cinnamaldehyde (CA) intervention in NS by utilizing computational pharmacology. Genes linked to NS were gathered from databases and then were used to construct a PPI network, of which the node importance values (Nim) were calculated utilizing an optimized algorithm.
View Article and Find Full Text PDFPLoS One
March 2025
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University.
Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome and often leads to end-stage renal disease. However, the underlying pathophysiological mechanisms that contribute to disease progression require further investigation to establish appropriate therapeutic targets and biomarkers. This study aimed to clarify the molecular mechanisms underlying FSGS by focusing on differentially expressed genes (DEGs) and lipid metabolism-related genes (LMRGs).
View Article and Find Full Text PDFClin Exp Nephrol
March 2025
Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan.
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