To simulate hidden epidemic dynamics connected with asymptomatic and unregistered patients, a new general SIR model was proposed. For some cases, the analytical solutions of the set of 5 differential equations were found, which allow simplifying the parameter identification procedure. Two waves of the pertussis epidemic in England in 2023 and 2024 were simulated with the assumption of zero hidden cases. The accumulated and daily numbers of cases and the duration of the second wave were predicted with rather high accuracy. If the trend will not change, the monthly figure of 9 new pertussis cases (as it was in January-February 2023) can be achieved only in May 2025. The proposed approach can be recommended for both simulations and predictions of different epidemics.
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http://dx.doi.org/10.3389/frai.2025.1559880 | DOI Listing |
Natl Sci Rev
April 2025
Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.
Gallium-based liquid metals, when combined with magnetic agents, emerge as intelligent materials with potential applications in soft robotics within biomedical engineering. However, concerns have arisen from the residual presence of liquid metal, raising long-term biological risks. Herein, we propose a containment method that involves the rolling of magnetic liquid-metal droplets in lyophilized powders, resulting in the formation of intact hydrogel coatings upon hydration.
View Article and Find Full Text PDFFront Artif Intell
February 2025
Institute of Hydromechanics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
To simulate hidden epidemic dynamics connected with asymptomatic and unregistered patients, a new general SIR model was proposed. For some cases, the analytical solutions of the set of 5 differential equations were found, which allow simplifying the parameter identification procedure. Two waves of the pertussis epidemic in England in 2023 and 2024 were simulated with the assumption of zero hidden cases.
View Article and Find Full Text PDFNat Commun
March 2025
Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Overcoming immunosuppression in the tumor microenvironment (TME) is crucial for developing novel cancer immunotherapies. Here, we report that IL-16 administration enhances the polarization of T helper 1 (Th1) cells by inhibiting glutamine catabolism through the downregulation of glutaminase in CD4 T cells and increases the production of Th1 effector cytokine IFN-γ, thus improving anti-tumor immune responses. Moreover, we find that establishing an IL-16-dependent, Th1-dominant TME relies on mast cell-produced histamine and results in the increased expression of the CXCR3 ligands in tumor-associated macrophages (TAM), thereby improving the therapeutic effectiveness of immune checkpoint blockade (ICB).
View Article and Find Full Text PDFHelicobacter
March 2025
Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
Introduction: Epidemiological and experimental studies have suggested that chronic H. pylori infection may be associated with colorectal cancer (CRC), a topic of growing interest. The Bradford-Hill criteria are the mainstay of the epidemiological approach to causal inference.
View Article and Find Full Text PDFSouth Asian J Cancer
October 2024
Clinical Services and Specialist Surgery, The Christie NHS Foundation Trust, Manchester, United Kingdom.
Evidence is mounting that circulating tumor deoxyribonucleic acid can be tested accurately, frequently, and in a noninvasive form. Its role in monitoring patients with cancer, particularly colorectal cancer, is increasing. In this brief review, we discuss its current role when measured using next-generation sequencing-based methods.
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