Background: The alarming rise in dengue cases and fatalities worldwide necessitates an in-depth analysis of essential public health functions (EPHFs) to fortify the resilience of health systems in the face of upcoming surges. This study focuses on the resilience of Brazil's health system in managing dengue from 2010 to 2024, leveraging machine learning techniques to correlate EPHF variables with dengue outcomes.
Methods: Utilizing public data from DATASUS and IBGE, we evaluated indicators such as healthcare workforce, health facilities, and dengue-specific data. A regression tree analysis identified associations between dengue hospitalizations and dengue deaths among Brazilian capitals, emphasizing the importance of strengthening outpatient services and monitoring systems for resilient performance.
Findings: This study revealed that capitals with fewer hospitalizations have seen recent improvements; nevertheless, continuous efforts are vital to prevent sudden surges. These findings underscore the critical role of health surveillance and community involvement in enhancing EPHF performance.
Interpretation: This research contributes to understanding the dynamic interactions within health systems and highlights the importance of proactive and integrated public health strategies to manage dengue and similar arboviruses.
Funding: The present study was funded by the Inova Fiocruz Program, grant 1366515559697323; and by the National Council for Scientific and Technological Development (CNPq), grant 401278/2022-0. Alessandro Jatobá is partially funded by CNPq, grants 307029/2021-2 and 405469/2023-3 and by the Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ), grant E-26/210.728/2023 and E-26/201.252/2022. Paulo Victor Rodrigues de Carvalho is partially funded by CNPq, grant: 304770/2020-5 and by FAPERJ, grant E-26/203.934/2024.
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http://dx.doi.org/10.1016/j.lana.2025.101042 | DOI Listing |
Am J Kidney Dis
March 2025
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
Critically ill patients that require kidney replacement therapy (KRT) are among the most ill and complex patients routinely encountered in the intensive care unit (ICU). Continuous KRT (CKRT) is used across many ICUs as the therapy of choice for hemodynamically unstable patients with kidney failure. Though existing trials have not shown superior survival or kidney recovery with CKRT relative to intermittent KRT, CKRT has largely become the standard of care in developed nations for the treatment of acute kidney injury (AKI) in patients with shock, acute brain injury, acute liver failure, and other forms of critical illness.
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March 2025
Nova Institute for Health, Baltimore, Maryland, USA.
Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles in human cognition and behaviour. Included in this research is evidence indicating that gut microbes, through direct and indirect pathways, can influence aggression, anger, irritability and antisocial behaviour. Moreover, gut microbes can manufacture chemicals that are known to compromise cognition.
View Article and Find Full Text PDFCells
March 2025
Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (Unesp), Botucatu 18618-689, São Paulo, Brazil.
Ovarian cancer (OC) is characterized by high mortality rates due to late diagnosis, recurrence, and metastasis. Here, we show that extracellular signaling molecules secreted by adipose-derived mesenchymal stem cells (ASCs) and OC cells-either in the conditioned medium (CM) or within small extracellular vesicles (sEVs)-modulate cellular responses and drive OC progression. ASC-derived sEVs and CM secretome promoted OC cell colony formation, invasion, and migration while upregulating tumor-associated signaling pathways, including TGFβ/Smad, p38MAPK/ERK1/2, Wnt/β-catenin, and MMP-9.
View Article and Find Full Text PDFCells
February 2025
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Preclinical studies have shown that the blood from female mice exposed weekly to magnetic fields inhibited breast cancer growth. This double-blind randomized controlled trial investigated whether analogous magnetic therapy could produce similar anticancer sera from human subjects. Twenty-six healthy adult females (ages 30-45) were assigned to either a magnetic therapy group, receiving twice weekly 1 mT magnetic exposures (10 min/session) for 4 weeks, or a control group, who underwent identical sham exposure.
View Article and Find Full Text PDFScand J Med Sci Sports
March 2025
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
High cardiorespiratory fitness (CRF) is associated with better overall health. This study aimed to find a metabolic signature associated with CRF to identify health-promoting effects. CRF based on cardiopulmonary exercise testing, targeted and untargeted metabolomics approaches based on mass spectrometry, and clinical data from two independent cohorts of the Study of Health in Pomerania (SHIP) were used.
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