Caries begin with an imbalance between demineralization and remineralization due to the continuous acid production by cariogenic bacteria. However, the development of dental materials that could prevent and treat caries a simple and efficient mechanism has always been a challenge. To address this issue, therapeutic nanoparticles composed of a dendritic polyglutamic acid (DPGlu) and chelerythrine (CHE) complex (DPGlu@CHE) were developed hydrophobic interactions and hydrogen bonds. DPGlu@CHE could be adsorbed onto the tooth surface, releasing CHE rapidly under acidic conditions to remove cariogenic bacteria, subsequently inducing tooth surface remineralization . Our results demonstrated that more than 99% of on the tooth surface were killed, and 84% of the mechanical properties of tooth were restored within 2 weeks. Thus, DPGlu@CHE was proven to be a safe and effective enamel restoration material , and its safety was verified , making it a promising mouthwash ingredient to maintain dental health.
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