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Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro.
Invest Ophthalmol Vis Sci
March 2025
Department of Bioengineering, University of Texas at Dallas, Richardson, Texas, United States.
Purpose: After stromal injury to the cornea, the release of growth factors and pro-inflammatory cytokines promotes the activation of quiescent keratocytes into a migratory fibroblast and/or fibrotic myofibroblast phenotype. Persistence of the myofibroblast phenotype can lead to corneal fibrosis and scarring, which are leading causes of blindness worldwide. This study aims to establish comprehensive transcriptional profiles for cultured corneal keratocytes, fibroblasts, and myofibroblasts to gain insights into the mechanisms through which these phenotypic changes occur.
View Article and Find Full Text PDFLeukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system.
J Exp Med
June 2025
Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Leukemia-driving mutations are thought to arise in hematopoietic stem cells (HSC), yet the natural history of their spread is poorly understood. We genetically induced mutations within endogenous murine HSC and traced them in unmanipulated animals. In contrast to mutations associated with clonal hematopoiesis (such as Tet2 deletion), the leukemogenic KrasG12D mutation dramatically accelerated HSC contribution to all hematopoietic lineages.
View Article and Find Full Text PDFUnraveling the impact of congenital deafness on individual brain organization.
Elife
March 2025
Department of Neuroscience, Georgetown University Medical Center, Washington DC, United States.
Research on brain plasticity, particularly in the context of deafness, consistently emphasizes the reorganization of the auditory cortex. But to what extent do all individuals with deafness show the same level of reorganization? To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. Our findings demonstrate remarkable differentiation between individuals deriving from the absence of shared auditory experiences, resulting in heightened FC variability among deaf individuals, compared to more consistent FC in the hearing group.
View Article and Find Full Text PDFGenomic differentiation and SNP variation reveal local adaptations to eastern Mediterranean environmental conditions in wild radishes.
Ann Bot
March 2025
Institute of Plant Sciences, Agricultural Research Organization, Rishon LeZion 7505101, Israel.
Background And Aims: Morphological differences between the two genetically close wild radishes, Raphanus raphanistrum and R. pugioniformis, include differences in fruit structure that influence their dispersal ability and within population spatial structure. Here, we tested within- and among-populations genetic variation, hypothesizing that (i) short-distance dispersal of heavy fruits in R.
View Article and Find Full Text PDFThe Histomorphology to Molecular Transition: Exploring the Genomic Landscape of Poorly Differentiated Epithelial Endometrial Cancers.
Cells
March 2025
SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP) Pan African Research Institute (PACRI), University of Pretoria, Hartfield, Pretoria 0028, South Africa.
The peremptory need to circumvent challenges associated with poorly differentiated epithelial endometrial cancers (PDEECs), also known as Type II endometrial cancers (ECs), has prompted therapeutic interrogation of the prototypically intractable and most prevalent gynecological malignancy. PDEECs account for most endometrial cancer-related mortalities due to their aggressive nature, late-stage detection, and poor response to standard therapies. PDEECs are characterized by heterogeneous histopathological features and distinct molecular profiles, and they pose significant clinical challenges due to their propensity for rapid progression.
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