Background: There is now widespread recognition within adolescence mental health research of the ethical imperative and benefits of coproduction. This has led to the development of best practice guidelines and the routine reporting of coproduction methods. However, there are unique considerations associated with involving young people in research with varying designs, e.g., longitudinal. Ideally, these decisions are made in consultation with young people themselves. Thus, the objective and novel contribution of this paper is (1) the involvement of young people in the development of the MHIM protocol, including an evaluative framework, and (2) a study protcol that utilises coproduction in the context of a longitudinal mental health project.
Methods: We present a coproduction protocol (MHIM-YPAG), developed with young people (pre-study YPAG), that describes the planned approach to involving young people in the MHIM study. MHIM will use an accelerated longitudinal-cohort design that will combine ecological momentary assessment, bio-sampling, radar-based sleep measurement and online questionnaires to examine the relationship between daily-life-experiences and adolescence mental health. The protocol describes how young people will be involved in MHIM and how impact will be evaluated. Within this context, coproduction relates to (1) the codevelopment, with young people, of the study's structure and (2) their involvement as researchers, e.g., recruitment, data interpretation and knowledge-exchange.
Patient Or Public Contribution: As one of the first protocols of its kind, our coproduction protocol, informed by literature and consultations with young people (pre-study YPAG), can provide a template for planning and reporting coproduction in mental health studies of adolescence.
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http://dx.doi.org/10.1111/hex.70218 | DOI Listing |
Elife
March 2025
Department of Neuroscience, Georgetown University Medical Center, Washington DC, United States.
Research on brain plasticity, particularly in the context of deafness, consistently emphasizes the reorganization of the auditory cortex. But to what extent do all individuals with deafness show the same level of reorganization? To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. Our findings demonstrate remarkable differentiation between individuals deriving from the absence of shared auditory experiences, resulting in heightened FC variability among deaf individuals, compared to more consistent FC in the hearing group.
View Article and Find Full Text PDFCancer Biol Med
March 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).
View Article and Find Full Text PDFJ Med Microbiol
March 2025
Department of Ophthalmology, Kazakh-Russian Medical University, 71 Torekulov Str., 050000, Almaty, Republic of Kazakhstan.
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View Article and Find Full Text PDFJ Int Med Res
March 2025
Infectious Diseases and Clinical Microbiology Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
ObjectivesAcute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context.
View Article and Find Full Text PDFWomens Health (Lond)
March 2025
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Objectives: To explore the levels and intersections of barriers to postpartum PC that exist external to the Medicaid policy.
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