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Outcomes of Older Adults With Delirium Discharged From the Emergency Department.
Ann Emerg Med
March 2025
Department of Emergency Medicine, Mayo Clinic, Rochester, MN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN. Electronic address:
Study Objective: To compare 30-day mortality and return emergency department (ED) visits among older adults with delirium who are discharged home with those discharged home without delirium and those who are admitted to the hospital with and without delirium.
Methods: Adults aged 75 and older years were assessed for delirium using the Delirium Triage Screen followed by the Brief Confusion Assessment Method. We evaluated outcomes including return visits and 30-day mortality.
Trifluoroacetic Acid Induced a Cyclophilin D-Dependent Cognitive Impairment in Mice.
Aging Dis
February 2025
Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Studies have linked inhalation anesthesia and surgery to increased cognitive impairment, particularly in the elderly. Our previous research showed that isoflurane, but not desflurane, affected cognitive function in mice by modulating cyclophilin D (CypD), a key regulator of the mitochondrial permeability transition pore (mPTP) and mitochondrial function. Both anesthetics metabolize into trifluoroacetic acid (TFA), which is associated with cognitive deficits.
View Article and Find Full Text PDFAddressing What Matters: A Pilot Study and Mixed Methods Evaluation of Patient Priorities Care in Four Clinical Settings.
J Am Geriatr Soc
March 2025
New England Geriatric Research, Education, and Clinical Centers (GRECC), VA Boston Healthcare System, Boston, Massachusetts, USA.
Background: Older adults with multiple chronic conditions face significant challenges with their health. Patient Priorities Care (PPC) is an Age-Friendly approach that explores 'what matters' by identifying values, care preferences, and health priorities, and aligning healthcare based on patients' health outcome goals.
Methods: Patient priorities care was implemented in four clinical settings (Hospital in Home, a transitional care case management program and in two embedded clinics within specialty care settings) within a large academically affiliated Veteran Affairs hospital system.
Intrinsic Capacity Trajectories: Implications for Subsequent Falls and Hospitalizations among Older Adults.
J Gerontol A Biol Sci Med Sci
March 2025
School of Public Health, Xiamen University, Xiamen, China.
Background: Intrinsic capacity (IC) is the composite of an individual's physical and mental capacities. However, the association between IC trajectories and falls and hospitalizations remains uncertain. This study aimed to determine the IC trajectories among older adults, investigating its association with subsequent risk of falls and hospitalizations.
View Article and Find Full Text PDFNovel, multimodal, simulation practice with evolving case scenario for teaching familial communications in undergraduate medical training.
Med Teach
March 2025
Centre for Healthcare Simulation, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
There is a growing recognition of the importance of familial involvement in patient care. In Asian societies, communications with patients' families for routine medical updates and shared decision-making are considered part-and-parcel of clinical practice. Yet, training in familial communications has remained, by and far, a neglected aspect of conventional communications skills training in the medical curriculum, despite distinctive nuances in the communications approach.
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