Endothelin-1 is a peptide derived from endothelial cells, consisting of 21 amino acid residues. In recent years, research has found that endothelin-1 not only plays a key role in vascular tone regulation but also participates in the occurrence and development of various types of pathological pain, including inflammatory pain, neuropathic pain, and cancer pain. Endothelin-1 binds to its receptors and activates multiple signaling pathways such as protein kinase C, calcium ion channels, and the phosphoinositide pathway, thereby influencing neuronal excitability and nociceptive information transmission. This article briefly reviews the current understanding of the mechanisms and potential roles of endothelin-1 in the development of pain, as well as commonly used endothelin-1 receptor antagonists, aiming to provide clues for better utilizing endothelin-1 and its receptors to alleviate and treat pathological pain.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
An In Situ Curing, Shear-Responsive Biomaterial Designed for Durable Embolization of Microvasculature.
Adv Healthc Mater
March 2025
Arsenal Medical, Inc, 100 Beaver Street, Suite 302, Waltham, MA, 02453, USA.
Endovascular embolization is a minimally-invasive technique whereby blood vessels supplying pathological structures are selectively occluded with various embolic agents. In many scenarios, it is desirable for the embolic to distally penetrate to the level of the microvasculature, which maximizes devascularization. Existing agents exhibit inconsistent distal penetration and have other limitations including tendency for proximal reflux, patient pain during infusion, lack of fluoroscopic radiopacity, potential for catheter adhesion, susceptibility to recanalization, and other usability challenges.
View Article and Find Full Text PDFBilateral Primary Central Nervous System's Lymphoma of Cerebellopontine Angles: A Case Report.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Primary central nervous system lymphoma (PCNSL) mostly occurs in supratentorial regions. Our patient underwent surgery because of headaches and pain and sensorineural hearing loss in his right ear and bilateral extra axial CPA mass in MRI. Histopathology reveals diffuse large B-Cell lymphoma.
View Article and Find Full Text PDFUltrastructural Analysis of Infected Absorbable Bone Fixation Material Using Scanning Electron Microscopy After Zygomatic Bone Fracture Surgery.
Plast Reconstr Surg Glob Open
March 2025
From the Department of Plastic, Reconstructive, and Aesthetic Surgery, School of Medicine, Chiba University, Chiba, Japan.
Absorbable bone fixation materials are commonly used in facial bone fracture surgery. However, reports on the microstructure of infected implants are rare. This study presents a case involving a 74-year-old male patient who developed an α- infection 2.
View Article and Find Full Text PDFBiomechanical assessment of unilateral/bilateral lumbar spondylolysis with and without muscle weakness using finite element analysis.
Heliyon
February 2025
Spine Research Center of Wannan Medical College, Wuhu, China, 22, Wenchang West Road, China, Wuhu, 241001, China.
Background: Spondylolysis is commonly linked to low back pain in athletes, and the connection between muscle weakness and spondylolysis is unclear. Therefore, this study examined the biomechanics of spondylolysis and influence of muscle weakness by finite element (FE) analysis.
Methods: A patient's L1-S1 lumbosacral unit was scanned by computed tomography, and generated a three-dimensional pathology-free FE model.
Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report.
Heliyon
February 2025
Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Italy.
A 55-year-old female patient affected by an EGFR mutant NSCLC with multiple lytic bone metastases and two prior pathological fractures, undergoing treatment with osimertinib and denosumab, participated in a 9-month physical exercise program. The exercise program was performed twice a week and consisted of aerobic and strength training. Aerobic training was composed of moderate-intensity continuous training for the first 3 months and then high-intensity interval training.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!