Relationships between multiple sleep outcomes, obesity and adiposity across childhood and adolescence have been previously reported. Health-promoting interventions to improve sleep and reduce adolescent obesity could target shared determinants of sleep and obesity. The aim of this systematic review was to systematically identify and examine research that investigated the shared determinants of poor sleep and increased adiposity or obesity in adolescents. A systematic literature search covering publications up to April 2024 was conducted across 10 bibliographic databases. Search terms included objective and subjective sleep/circadian rhythm measurements, objective adiposity measurements and adolescents aged 8-18 years. Eighty studies were included in the final review. Determinants were categorised into three different domains: socioenvironmental determinants, behavioural determinants and health determinants. Shared determinants of poor sleep and increased adiposity or obesity in adolescents aged 8-18 years included: socioenvironmental determinants (gender, ethnicity, pubertal status, academic attainment), behavioural determinants (timing of moderate-to-vigorous physical activity (MVPA), unhealthy diet choices and timing of consumption and screen time and videogaming quantity and timing) and health determinants (wellbeing). These findings suggest that sleep hygiene and the modifiable shared behavioural determinants should be targeted in health-promoting interventions, and statistical analyses should be adjusted for socioenvironmental determinants and wellbeing.
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http://dx.doi.org/10.1111/jsr.70029 | DOI Listing |
Transl Behav Med
January 2025
Section of Infectious Diseases, Department of Medicine, Boston University Chobanian and Avedesian School of Medicine/Boston Medical Center, 801 Massachusetts Avenue, Boston, MA 02118, USA.
Background: The Supplemental Nutrition Assistance Program (SNAP) is an underutilized program. SNAP uptake is limited in Latine households in particular due to concerns about immigration eligibility, even when there are SNAP-eligible household members. Implementation strategies are urgently needed to increase SNAP participation rates among those who are eligible.
View Article and Find Full Text PDFCurr Opin Urol
March 2025
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Purpose Of Review: To evaluate the role of extirpative surgery for the primary tumor in metastatic upper tract urothelial carcinoma (mUTUC).
Recent Findings: The PubMed, Web of Science, and Cochrane Library were searched on July 2024 to identify relevant studies according to the Preferred Reporting Items for Systematic Review (PRISMA) statement. Studies were eligible for analysis if they compared oncologic outcomes between mUTUC patients who underwent surgical resection of the primary tumor and patients who did not.
J Agric Food Chem
March 2025
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
The mycotoxin patulin in processed apple juice poses a significant threat to food safety, driving the need for effective detoxification strategies. ATCC 621 can detoxify patulin to ascladiol using either the short-chain dehydrogenases/reductases (SDRs)─GOX0525, GOX1899, and GOX0716─or the aldo-keto reductase (AKR) GOX1462. While GOX0525 and GOX1899 have been previously characterized, this study focuses on GOX0716 and GOX1462, evaluating their optimal pH, thermostability, thermoactivity, and substrate specificity, thereby completing the characterization of all four reductases.
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Immuno-Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
In recent years, the rapid progress in oncology, immunology, and molecular biology has dramatically advanced cancer immunotherapy, particularly CAR-T cell therapy. This innovative approach involves engineering a patient's T cells to express receptors that specifically target tumor antigens, enhancing their ability to identify and eliminate cancer cells. However, the effectiveness of CAR-T therapy in solid tumors is often hampered by the challenging tumor microenvironment (TME).
View Article and Find Full Text PDFJ Pain Res
March 2025
Division of Pharmaceutical Evaluation and Policy, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Importance: This study addresses the critical need for an evidence-based instrument to assess the likelihood of NSAID-induced cardiovascular events, that provides clinicians with valuable decision support to improve safety in their use for pain management, especially in patients vulnerable to cardiovascular events.
Objective: To develop a practical risk scoring tool, NSAID Induced Cardiovascular Events (NAÏVE), for estimating the risk of serious cardiovascular events associated with NSAID use.
Design: Retrospective nested case-control study.
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