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Mediation Analysis of Gut Microbiota and Plasma Metabolites in Asthma Pathogenesis Using Mendelian Randomization.
J Asthma
March 2025
Department of Emergency, Wujin Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, 213017, Jiangsu, China.
Asthma is a prevalent chronic respiratory condition with multifactorial pathogenesis. Emerging evidence suggests that gut microbiota and their metabolites influence asthma risk. This study explores the mediation effects of plasma metabolites between gut microbiota and asthma using Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFComposite quantile regression approach to batch effect correction in microbiome data.
Front Microbiol
February 2025
Department of Statistics, Seoul National University, Seoul, Republic of Korea.
Background: Batch effects refer to data variations that arise from non-biological factors such as experimental conditions, equipment, and external factors. These effects are considered significant issues in the analysis of biological data since they can compromise data consistency and distort actual biological differences, which can severely skew the results of downstream analyses.
Method: In this study, we introduce a new approach that comprehensively addresses two types of batch effects: "systematic batch effects" which are consistent across all samples in a batch, and "nonsystematic batch effects" which vary depending on the variability of operational taxonomic units (OTUs) within each sample in the same batch.
TaiChi-MSS protocol: enhancing cognitive and brain function in MCI patients through Tai Chi exercise combined with multisensory stimulation.
Front Aging Neurosci
February 2025
School of Wushu, Shanghai University of Sport, Shanghai, China.
Background: The aging population in China is confronted with considerable challenges, with 14.71% of elderly individuals affected by mild cognitive impairment (MCI). The practice of Tai Chi has been demonstrated to enhance cognitive function, while sensory stimulation has been shown to facilitate neural activity.
View Article and Find Full Text PDFCase Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient.
Front Oncol
February 2025
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.
Introduction: We report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma.
Case Discussion: A 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging revealed an inferior vena cava thrombus associated with a complex mass.
A Prospective Study on Anemia in Hypothyroidism and Hyperthyroidism.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Otorhinolaryngology, JJM Medical College, Davangere, Karnataka India.
Anemia is a common condition associated with thyroid diseases but the causal relationship between these disorders remains unclear. Thyroid hormones play a crucial role in erythropoiesis by stimulating the expression of the erythropoietin gene and erythropoietin production. An excess of thyroid hormones is also linked to altered iron metabolism or oxidative stress.
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