Background: Patients on peritoneal dialysis (PD) frequently have cognitive impairment, which is linked to a poor prognosis. The purpose of this study was to determine whether abdominal aortic calcification (AAC) may have an impact on PD patients' cognitive function.
Methods: In this cross-sectional study of 110 PD patients, cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and AAC severity was quantified via lateral lumbar radiography (Kauppila method). Participants were stratified by AAC severity into high (HAAC; score ≥ 4) and low (LAAC; score < 4) groups.
Results: Cognitive impairment (MoCA < 26) was present in 65.45% of patients. The HAAC group (71.8% of cohort) exhibited distinct metabolic profiles compared to LAAC: older age (63.2 ± 9.8 vs. 47.4 ± 12.1 years, P < 0.001), higher diabetes prevalence (68.4% vs. 22.6%, P < 0.001), elevated serum phosphorus (1.62 ± 0.45 vs. 1.30 ± 0.42 mmol/L, P < 0.001), and lower diastolic blood pressure (79.2 ± 10.8 vs. 86.6 ± 13.4 mmHg, P = 0.005). Notably, HAAC patients had reduced serum creatinine (898.4 ± 251.9 vs. 1190.7 ± 243.5 µmol/L, P < 0.001) and iPTH levels (142.5 vs. 218.0 pg/mL, P = 0.011), suggesting concurrent mineral bone disorder. Multivariate analysis identified AAC severity (OR = 1.28 per 1-point increase, 95%CI = 1.09-1.50) and age (OR = 1.12/year, 95%CI = 1.06-1.19) as independent predictors of cognitive impairment.
Conclusion: AAC severity demonstrates a strong, dose-dependent association with cognitive dysfunction in PD patients, independent of traditional risk factors. The combination of elevated phosphorus and suppressed iPTH in high-AAC patients highlights the potential role of mineral metabolism dysregulation in both vascular calcification and neurocognitive decline.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1186/s12882-025-04056-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The celiac ganglia and trunk: an assessment of anatomical variants and their clinical relevance.
J Med Life
January 2025
Discipline of Anatomy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
The celiac ganglia are a network of nerve fibers that regulate various functions related to digestion, while the celiac trunk is a major artery that supplies oxygenated blood to the stomach, small intestine, and other organs in the upper abdominal region. Anatomical variants of these structures are common and can have significant implications for surgical and medical procedures. This prospective observational study was conducted over one year and included 300 patients (aged 45-75 years) with a history of peripheral arterial disease, evaluated at Dr.
View Article and Find Full Text PDFTemporal trends and outcomes for the treatment of acute aortic occlusion from 2009 to 2020 in Germany.
Vasa
March 2025
Department for Vascular and Endovascular Surgery and Munich Aortic Center (MAC), University Hospital rechts der Isar, Technical University Munich (TUM), Germany.
Acute abdominal aortic occlusion is a rare vascular emergency associated with high morbidity and mortality. To date, the topic has hardly been addressed scientifically. Most case series are afflicted with small cohort numbers.
View Article and Find Full Text PDFThe correlation between muscle loss and the severity of vascular stenosis in elderly patients with peripheral artery disease: a retrospective analysis utilizing computed tomography.
Aging Clin Exp Res
March 2025
Department of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Background: Peripheral artery disease (PAD) is a globally prevalent atherosclerotic disease associated with an increased risk of cardiovascular and cerebrovascular diseases and a poor prognosis. Skeletal muscle loss (sarcopenia) is particularly common in patients with PAD and is closely associated with poor prognosis.
Aims: The aim of this study was to evaluate the area, density and fat infiltration of skeletal muscle in patients with PAD by CT, and to analyze their relationship with the degree of vascular stenosis.
A case of fatal acute saddle embolism of the terminal aorta after long-term support using Impella CP.
J Artif Organs
March 2025
Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, 2-5-1 Nakaicho, Kita-ku, Okayama, 700-0804, Japan.
A 69-year-old male diagnosed with subacute myocardial infarction was subsequently transferred to our institution. Upon admission, echocardiography revealed ventricular septal rupture (VSR). The patient was promptly supported via venoarterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella CP before surgical VSR repair on the 12th day of admission.
View Article and Find Full Text PDFAssociations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA).
Hum Immunol
March 2025
Department of Orthopaedic Surgery, University of California, San Diego, United States. Electronic address:
Objective: Rheumatoid arthritis (RA) has been considered an independent risk factor for cardiovascular disease (CVD), where RA and CVD later manifest following genetic predisposition and an extended preclinical phase.TheHLA-DRB1Shared Epitope (SE)allelespredispose for RA andare associated withhigherrisk of CV mortality in RA patients, but have not been evaluated in a community-living population.Thus, we evaluated whetherHLA-DRB1 (SE) alleleswereassociated with subclinical CVD, CV events, and mortality in the Multi-Ethnic Study of Atherosclerosis (MESA).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!