Background: The novel coronavirus disease, which is a global public health issue, changed the regular lifestyle of public globally causing multitude of stressors. This study aimed to describe the perception regarding the COVID-19 pandemic among an online sample of adults in Sri Lanka.
Methods: A descriptive exploratory study was conducted with a purposive selected sample of general public in Sri Lanka. Twelve in-depth interviews were conducted using a semi-structured interview guide until data saturation. The data were analyzed using thematic analysis.
Results: All participants were below 50 years and educated upto advanced level. Seven themes were identified based on in-depth interviews; (1) traditional views regarding disease; (2) fear; (3) disrupted future plans; (4) impaired sense of responsibilities; (5) intense work stress (6) time to cherish, and (7) anticipated adjustments for future pandemics.
Conclusions: People have experienced fear, uncertainty, distracted future plans, and work stress due to the pandemic. However, they have also enjoyed spending time with their family members during this period.
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http://dx.doi.org/10.1186/s12889-025-22168-7 | DOI Listing |
Importance: Exercise intervention studies have shown benefits for patients with lung cancer undergoing surgery, yet most interventions to date have been resource intensive and have followed a one-size-fits-all approach.
Objective: To determine whether a personalized, clinic-aligned perioperative exercise program with remote monitoring and instructions can improve physical function and fatigue among patients undergoing surgery for lung cancer.
Design, Setting, And Participants: The Precision-Exercise-Prescription (PEP) randomized clinical trial is a single-center phase 3 trial.
Stat Med
March 2025
Vaccine and Infectious Disease and Public Health Sciences Divisions, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Based on data from a randomized, controlled vaccine efficacy trial, this article develops statistical methods for assessing vaccine efficacy (VE) to prevent COVID-19 infections by a discrete set of genetic strains of SARS-CoV-2. Strain-specific VE adjusting for possibly time-varying covariates is estimated using augmented inverse probability weighting to address missing viral genotypes under a competing risks model that allows separate baseline hazards for different risk groups. Hypothesis tests are developed to assess whether the vaccine provides at least a specified level of VE against some viral genotypes and whether VE varies across genotypes.
View Article and Find Full Text PDFHealth Expect
April 2025
Department of General Practice, Université Clermont Auvergne, UFR Medicine, Clermont-Ferrand, France.
Introduction: Health restrictions resulting from COVID-19 made it more difficult for families to mourn. The death announcement is a significant moment for families. The aim of this study was to explore the experiences, perceptions and expectations of families who were informed of the death of a close relative in the hospital, at home or in a care home for dependent elderly people (EHPAD) during the COVID-19 pandemic.
View Article and Find Full Text PDFLiver Int
April 2025
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease globally. MASLD is a multisystem disease where metabolic dysfunction plays a key role in the development of MASLD and its most relevant liver-related morbidities and extrahepatic complications, such as cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers. Among the least examined MASLD-related extrahepatic complications, an ever-increasing number of observational studies have reported a positive association between MASLD and the risk of serious bacterial infections (SBI) requiring hospital admission.
View Article and Find Full Text PDFCells
February 2025
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil.
The progression of COVID-19 involves a sophisticated and intricate interplay between the SARS-CoV-2 virus and the host's immune response. The immune system employs both innate and adaptive mechanisms to combat infection. Innate immunity initiates the release of interferons (IFNs) and pro-inflammatory cytokines, while the adaptive immune response involves CD4+ Th lymphocytes, B lymphocytes, and CD8+ Tc cells.
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