Background: Multiple Sclerosis (MS) is a long-term condition affecting the central nervous system that typically manifests in young adults. Stigma poses significant psychosocial challenges for patients with MS, negatively impacting their personal and social lives. However, limited research has examined how MS-related stigmatization influences marriage. This study focused on unmarried individuals aged 20-40 years in Iran to determine the prevalence of societal stigma and their willingness to marry someone with MS.
Methods: A researcher-designed questionnaire was used to collect data from 343 unmarried individuals in a cross-sectional study. In-person interviews were conducted to assess participants' overall understanding of MS and their views on marrying someone with the condition. The questionnaire measured sociodemographic variables and the degree of stigmatization toward MS by including concerns related to marriage with MS patients and their families.
Results: Data were collected from 343 participants (53% female), with a mean age of 25.96 ± 6.05 years. Overall, 77.6% expressed reluctance to marry someone diagnosed with MS-primarily due to concerns about physical disabilities. Additionally, 47.2% were hesitant if a potential spouse's parent had MS, while 46.6% and 28.4% reported similar reservations regarding siblings and second-degree relatives, respectively. Participants employed in healthcare fields demonstrated significantly lower levels of stigma (p = 0.031). Younger individuals tended to hold more stigmatizing views (p = 0.04), and significant variations were also observed across different ethnic groups (p < 0.001).
Conclusions: This study contributes to a more nuanced understanding of the social consequences of MS by providing valuable insights that can inform the development of strategies aimed at mitigating societal stigma. By enhancing awareness and promoting supportive interventions, it is possible to cultivate an inclusive environment that not only improves the quality of life for those affected by MS but also reduces stigma across various social contexts, including interpersonal relationships and marital dynamics.
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http://dx.doi.org/10.1186/s12883-025-04092-w | DOI Listing |
BMC Neurol
March 2025
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: Multiple Sclerosis (MS) is a long-term condition affecting the central nervous system that typically manifests in young adults. Stigma poses significant psychosocial challenges for patients with MS, negatively impacting their personal and social lives. However, limited research has examined how MS-related stigmatization influences marriage.
View Article and Find Full Text PDFTurk J Obstet Gynecol
March 2025
Ahvaz Jundishapur University of Medical Sciences, Diabetes Research Center, Health Research Institute, Ahvaz, Iran.
Objective: Recurrent spontaneous abortion (RSA), characterized by multiple miscarriages without a known cause, includes both genetic and non-genetic factors. In this research, we studied the association between two polymorphisms of the and genes and RSA for the first time in the southwest of Iran.
Materials And Methods: This was a case-control study involving 62 patients with a history of at least two RSA of unknown etiology, as well as 66 healthy individuals.
Cureus
February 2025
Pathology and Laboratory Medicine, Aga Khan University, Karachi, PAK.
Objective This study aimed to verify the methods used for biotinidase deficiency (BTD) assays, including fluorometric and colorimetric techniques, measure biotinidase (BT) activity in dried blood spots (DBS) and serum samples, and explore the clinical spectrum of patients with BTD based on low serum BT activity. Methods A cross-sectional study was conducted at the Newborn Screening Lab, Aga Khan University, Karachi, following ethical approval from August 2021 to December 2024. The study was conducted in three phases.
View Article and Find Full Text PDFClin Rheumatol
March 2025
Public Authority of Food and Nutrition, Sabah Al Salem, Kuwait.
Introduction/objectives: Rheumatic and musculoskeletal diseases (RMD) are prevalent among Arabic-speaking patients in the Middle East and North Africa (MENA), yet their perspectives remain underexplored. This study examines patient experiences and perspectives.
Method: A cross-sectional survey was developed using pilot testing with clinimetric sensibility assessment to ensure clarity and relevance, and the Open-Source Metric for Measuring Arabic Narratives (OSMAN) to assess readability.
Mol Biol Rep
March 2025
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Hearing loss (HL) is a highly heterogeneous condition with concerning statistics, particularly given the significant occurrence of consanguineous marriages in Iran. Despite the presence of variants of uncertain significance (VUS), high-yield prenatal screening remains unattainable. This article aims to discuss a VUS mutation as a potential cause of HL in a sibling, with the goal of reclassifying this variant.
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