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Circulating Blood-Based Proteins in Psychopathology and Cognition: A Mendelian Randomization Study.
JAMA Psychiatry
March 2025
Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, New York.
Importance: Peripheral (blood-based) biomarkers for psychiatric illness could benefit diagnosis and treatment, but research to date has typically been low throughput, and traditional case-control studies are subject to potential confounds of treatment and other exposures. Large-scale 2-sample mendelian randomization (MR) can examine the potentially causal impact of circulating proteins on neuropsychiatric phenotypes without these confounds.
Objective: To identify circulating proteins associated with risk for schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) as well as cognitive task performance (CTP).
The PP2A-B56 Binding Site LxxIxE Contributes to Asp-Mediated Spindle Pole Stability.
Cytoskeleton (Hoboken)
March 2025
Biology Department, Mount Saint Vincent University, Halifax, Canada.
The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule-associated protein required for correct mitotic spindle formation. To better understand the contribution of Asp to microtubule organization during spindle formation, we reverse-engineered flies to express a version of Asp (Asp), predicted to have lost its ability to bind the phosphatase trimer PP2A-B56.
View Article and Find Full Text PDFSociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank.
Psychol Med
March 2025
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Background: In major depressive disorder (MDD), only ~35% achieve remission after first-line antidepressant therapy. Using UK Biobank data, we identify sociodemographic, clinical, and genetic predictors of antidepressant response through self-reported outcomes, aiming to inform personalized treatment strategies.
Methods: In UK Biobank Mental Health Questionnaire 2, participants with MDD reported whether specific antidepressants helped them.
Correction: Achieving 9% EQE in light-emitting electrochemical cells a TADF-sensitized fluorescence strategy.
Phys Chem Chem Phys
March 2025
Key Laboratory of Photochemistry, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Correction for 'Achieving 9% EQE in light-emitting electrochemical cells a TADF-sensitized fluorescence strategy' by Zeyang Zhou , , 2024, , 24498-24505, https://doi.org/10.1039/D4CP02801E.
View Article and Find Full Text PDFCorrection: Molecular characterization and risk analysis of Giardia duodenalis assemblages in corticosteroid-treated and non-treated patients in Ismailia, Arab Republic of Egypt.
Gut Pathog
March 2025
Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
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