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Tribological Behavior and Mechanism of Silane-Bridged h-BN/MoS2 Hybrid Filling Epoxy Solid Lubricant Coatings.
Nanomaterials (Basel)
March 2025
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
To significantly improve the tribological performance of epoxy resin (EP), a novel h-BN/MoS composite was successfully synthesized using spherical MoS particles with lamellar self-assembly generated through the calcination method, followed by utilizing the "bridging effect" of a silane coupling agent to achieve a uniform and vertically oriented decoration of hexagonal boron nitride (h-BN) nanosheets on the MoS surface. The chemical composition and microstructure of the h-BN/MoS composite were systematically investigated. Furthermore, the enhancement effect of composites with various contents on the frictional properties of epoxy coatings was studied, and the mechanism was elucidated.
View Article and Find Full Text PDFStabilizing Ru in Multicomponent Alloy as Acidic Oxygen Evolution Catalysts with Machine Learning-Enabled Structural Insights and Screening.
J Am Chem Soc
March 2025
Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, California 94720, United States.
Developing active, stable, and cost-effective acidic oxygen evolution reaction (OER) catalyst is a critical challenge in realizing large-scale hydrogen (H) production via electrochemical water splitting. Utilizing highly active and relatively inexpensive Ru is generally challenged by its long-term durability issue. Here, we explore the potential of stabilizing active Ru sites in Ru(Ir,Fe,Co,Ni) multicomponent alloy by investigating its phase formation behavior, OER performance, and OER-induced surface reconstruction.
View Article and Find Full Text PDFProtocol of the IMPACT study: randomized, multicenter, phase 3 study evaluating the efficacy of immunotherapy (Atezolizumab) plus anti-VEGF therapy (Bevacizumab) in combination with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma.
BMC Cancer
March 2025
Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Background: Atezolizumab plus bevacizumab is recommended as a first-line treatment for unresectable hepatocellular carcinoma (uHCC). A subgroup analysis of the IMbrave150 trial showed shorter overall survival (OS) in uHCC patients with stable disease (SD) than patients with complete response (CR) or partial response (PR) after atezolizumab plus bevacizumab. Improving OS in patients with SD is an unmet medical need.
View Article and Find Full Text PDFRestoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia.
Cancer Cell
March 2025
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address:
Chimeric antigen receptor (CAR) T cells induce responses in patients with relapsed/refractory leukemia; however, long-term efficacy is frequently limited by relapse. The inability to target antigen-low cells is an intrinsic vulnerability of second-generation CAR T cells and underlies most relapses following CD22BBz CAR T cell therapy. Here, we interrogate CD22BBz CAR signaling in response to low antigen and find inefficient phosphorylation of the linker for activation of T cells (LAT) limiting downstream signaling.
View Article and Find Full Text PDFBeneficial effect of Juncus effusus extract powder enriched with dehydroeffusol on the cognitive and dexterous performance of elderly people: A randomized, double-blind, placebo-controlled, parallel-group study.
Nutrition
February 2025
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan.
On the basis of the evidence that dehydroeffusol prevents human amyloid-β-induced memory deficit and neurodegeneration in mice, here we tested the effect of a Juncus effusus extract powder enriched with dehydroeffusol on the cognitive and dexterous performance of elderly people. A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 41 participants (averaged age: 69 years) randomly divided into test and placebo groups who received a test tablet and a placebo tablet, respectively, once a day for 24 weeks. Changes in cognitive function were assessed using the Five-Cog test 24 weeks after the start of intake.
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