Moderation effects in longitudinal structural equation models are often analysed using latent variable product terms, which can be complex and difficult to estimate, especially in large models with many panel waves. An alternative approach for categorical moderation variables is the simpler technique of multiple-group comparisons. This method allows for straightforward model specification and precise differentiation of effects in complex models. This tutorial demonstrates multiple-group comparisons using examples based on developmental trajectories of juvenile delinquency. These trajectories are modelled via a latent growth curve approach, treating the variables as count data and applying Bayesian estimation using the software Mplus. The results are processed using the R programming language. This method addresses challenges associated with maximum likelihood estimation, particularly for latent growth models with count variables and additional exogenous latent variables. The analysis examines group differences by gender and school type in the trajectories of an unconditional growth model. It also examines the effect of legal norm acceptance on these trajectories using a conditional growth model. The moderating effects of gender and school type on these effects are analysed separately. The results reveal group differences of gender and school type for the unconditional growth model, while the conditional growth model highlights a moderating effect of school type on the relationship between legal norm acceptance and growth trajectories.
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http://dx.doi.org/10.3758/s13428-025-02624-3 | DOI Listing |
Emerg Microbes Infect
March 2025
School of Biomedical Sciences, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong.
Mpox virus (MPXV) has to establish efficient interferon (IFN) antagonism for effective replication. MPXV-encoded IFN antagonists have not been fully elucidated. In this study, the IFN antagonism of poxin-schlafen (PoxS) fusion gene of MPXV was characterized.
View Article and Find Full Text PDFCirc Heart Fail
March 2025
Department of Medicine, University of Maryland School of Medicine, Baltimore (M.T.G.).
Background: Despite favorable hemodynamic and neurohormonal effects, endothelin receptor antagonists have not improved outcomes in patients with heart failure (HF), possibly because they cause fluid retention.
Methods: In this randomized, double-blind, multicenter trial (SERENADE [Macitentan in Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease]), we evaluated the effects of an endothelin receptor antagonist, macitentan, in patients with HF, left ventricular ejection fraction ≥40%, and pulmonary vascular disease. After a 4-week placebo run-in (to ensure clinical stability), followed by a 5-week single-blind macitentan run-in, patients who did not exhibit fluid retention were randomized to macitentan or placebo.
Nutr Hosp
March 2025
Facultad de Medicina. Universidad de Castilla-La Mancha.
Introduction: currently there are changes in lifestyle that have been modifying the nutritional culture, moving away from the Mediterranean diet (DMed) and acquiring a more sedentary lifestyle, a fact that has contributed to a significant increase in risk factors. (CVRF) such as obesity and type 2 diabetes mellitus (DM2), and consequently to a global increase in metabolic syndrome (MS) and cardiovascular diseases (CVD), which in the 21st century reinforces being the first cause of morbidity and mortality To reduce this pandemic, a multidisciplinary approach is required focused on the application of primary and secondary prevention strategies for modifiable CVRFs, focused on nutritional promotion and education through the promotion of a healthier lifestyle and diet from childhood, as the one that encompasses the MedD. This dietary pattern, together with physical exercise, has been shown to contribute to the primary and secondary prevention of DM2 and coexisting CVRF.
View Article and Find Full Text PDFAIDS Care
March 2025
Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Older people with HIV (OPWH) have an increased risk of type 2 diabetes mellitus (T2DM). Understanding this is important to screen and initiate treatments. This study explored awareness of T2DM, perceived risk, and willingness to receive T2DM preventive education.
View Article and Find Full Text PDFAutophagy
March 2025
Department of Critical Care Medicine and Emergency, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cardiac dysfunction is a serious complication of sepsis-induced multiorgan failure in intensive care units and is characterized by an uncontrolled immune response to overwhelming infection. Type 2 innate lymphoid cells (ILC2s), as a part of the innate immune system, play a crucial role in the inflammatory process of heterogeneous cardiac disorders. However, the role of ILC2 in regulating sepsis-induced cardiac dysfunction and its underlying mechanism remain unknown.
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