Background: Soluble Alpha-Klotho (S-αklotho) protein and 25-Hydroxyvitamin D (25-OH-D) have emerged as potential modulators for activating and recruiting Brown Adipose Tissue (BAT). The present study aimed to investigate whether circulating S-αklotho and 25-OH-D levels are related to BAT volume, Fluorine-Fluorodeoxyglucose (F-FDG) uptake, and BAT radiodensity in young healthy adults.
Methods: A total of 128 participants (68% women) aged 18-25 years old participated in this cross-sectional study. Serum levels of S-αklotho were determined by a solid-phase sandwich enzyme-linked immunosorbent assay kit and 25-OH-D serum levels were analyzed using a competitive chemiluminescence immunoassay, both in blood samples collected after an overnight fast. All participants underwent a personalized cold exposure to determine their BAT volume, F-FDG uptake, and radiodensity, using a static positron emission tomography combined with computed tomography scan.
Results: After adjusting for multiple covariates, serum levels of S-αklotho (all R ≤ 0.228 and P ≥ 0.364), 25-OH-D as continuous (all R ≤ 0.242 and P ≥ 0.088) or by vitamin D status (all R ≤ 0.767 and P ≥ 0.061) were not associated with either BAT volume and F-FDG uptake, or BAT radiodensity.
Conclusion: Serum S-αklotho and 25-OH-D levels within the physiological range are not related to BAT-related variables in young healthy adults. Further studies are needed to fully understand the underlying mechanisms involved in BAT metabolism in humans. (ACTIBATE; ClinicalTrials.gov identifier: not applicable).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s13105-025-01072-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: This study aimed to investigate the effects of total antioxidant capacity (T-AOC), superoxide dismu-tase (SOD), and malondialdehyde (MDA) in blood on the postoperative wound healing process of patients with severe burns treated by Meek micrografting.
Methods: In total, 154 patients with severe burns who underwent Meek micrografting treatment were selected as the observation group, and 80 healthy people were taken as the control group. General clinical data were collected, and serum T-AOC, SOD, and MDA were analyzed by biochemical analysis.
Background: Tuberculosis is still a significant global health challenge, with latent tuberculosis infection (LTBI) posing a risk for the development of active disease. This study aimed to compare the performance of the STAN-DARD F TB-Feron FIA test with the QuantiFERON-TB Gold Plus, a test endorsed by the World Health Organization (WHO), in detecting LTBI.
Methods: We included 137 participants, out of which 58.
Cardiovascular Risk and Plasma N-terminal Pro-B-type Natriuretic Peptide in Adults With Resistance to Thyroid Hormone β.
J Endocr Soc
March 2025
Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Purpose: People with resistance to thyroid hormone due to defective thyroid receptor β (RTHβ) exhibit adverse cardiovascular outcomes and premature mortality. Whether this reflects increased global cardiovascular disease (CVD) risk or hyperthyroxinemia-associated effects on cardiac rhythm and contractility is unknown. We determined CVD risk and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations as a marker of reduced cardiac function in 99 individuals (mean age 41 years, 37% males) with RTHβ.
View Article and Find Full Text PDFUnusual Presentation of Nasal Myiasis in Immunocompetent Young Individual: Case Report.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pillaiyarkuppam, 607402 Pondicherry India.
Background: Nasal myiasis, an infestation by fly larvae, is a rare condition typically associated with immunocompromised individuals, poor hygiene, and low socioeconomic status. It is commonly seen in tropical regions and is often linked to chronic sinonasal diseases or underlying health conditions. However, cases in healthy individuals without predisposing factors are uncommon, making this case novel and worthy of documentation.
View Article and Find Full Text PDFSelf-reported history of head injury is associated with cognitive impulsivity on a delay discounting task.
PeerJ
March 2025
Research and Development Service, VA New Jersey Health Care System, East Orange, NJ, United States of America.
Background: Head injuries are a major health care concern that can produce many long lasting cognitive, mental, and physical problems. An emerging literature indicates increased impulsivity in patients with a history of traumatic brain injury (TBI). In a recent study, Veterans with clinically-assessed history of mild TBI had increased cognitive, but not motor, impulsivity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!