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Advances in Therapy of Adult Patients with Acute Lymphoblastic Leukemia.
Cells
March 2025
Department of Hematology and Medical Oncology, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USA.
The landscape of adult acute lymphoblastic leukemia (ALL) is dramatically changing. With very promising results seen with novel immunotherapeutics in the setting of relapsed and refractory disease, the prospect of using these agents in first-line therapy has prompted the development of multiple clinical trials addressing this question. This review seeks to outline and expand the current standard of care, as well as new advances, in the treatment of adult patients with ALL and address future areas of research.
View Article and Find Full Text PDFEffect of abatacept added to mycophenolate mofetil for refractory calcinosis in juvenile dermatomyositis.
Mod Rheumatol Case Rep
March 2025
Department of Infection and Immunology, Allergy and Immunology Center, Aichi Children's Health and Medical Center, Aichi, Japan.
Calcinosis is an intractable condition in juvenile dermatomyositis. The effect of abatacept on calcinosis remains controversial. We describe a case of an 8-year-old boy in whom the addition of abatacept to mycophenolate mofetil was effective against calcinosis in juvenile dermatomyositis.
View Article and Find Full Text PDFRegional anesthesia for arrhythmias: a review of current literature.
Curr Opin Anaesthesiol
February 2025
Department of Anesthesiology and Perioperative Medicine; University of Texas Medical Branch, Galveston, Texas, USA.
Purpose Of The Review: The aim is to provide a comprehensive review of regional anesthesia techniques to control ventricular arrhythmias.
Recent Findings: While promising, the use of stellate ganglion block (SGB) for arrhythmia control is still under investigation, and further clinical trials are warranted to fully understand its efficacy, long-term outcomes, suitable patient group, and safety profile. Nevertheless, it remains a potential adjunctive therapy in the management of ventricular arrhythmias in select patients.
Transscleral Cyclophotocoagulation for Refractory Intraocular Pressure Elevation after Penetrating Keratoplasty.
J Glaucoma
March 2025
Department of Ophthalmology, Saarland University Medical Centre, Homburg/ Saar, Germany.
Prcis: Transscleral cyclophotocoagulation significantly reduces intraocular pressure and antiglaucomatous medication use post-penetrating keratoplasty, with low hypotony risk, particularly if delayed. Safe reintervention is feasible for intraocular pressure recurrence.
Purpose: Transscleral cyclophotocoagulation (TSCPC) is an established procedure for lowering intraocular pressure (IOP).
Spleen Involvement at Diagnosis of Multiple Myeloma: A Case Report and Literature Review.
Cancer Rep (Hoboken)
March 2025
UOC Haematology, ASL Viterbo-Santa Rosa Hospital, Viterbo, Italy.
Background: Multiple myeloma (MM) is more often characterized by clonal plasma cell proliferation restricted to the bone marrow. However, a small percentage of patients with MM develop extramedullary disease (EMD): this type of localization is found in 1.7%-4.
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