The author comments on the recent paper by Cheng et al describing a series of MWS patients derived from a much larger series of HSCR patients. Children operated for HSCR with developmental delay suffer more difficulties than children without, but the literature varies on the outcomes associated with developmental delay such as Down syndrome and MWS. The author suggests that the degree of developmental delay has a bearing on outcome, and he further asks whether MWS has any particular features to make its prognosis different from other developmental delay syndromes associated with HSCR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpedsurg.2025.162272 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The PP2A-B56 Binding Site LxxIxE Contributes to Asp-Mediated Spindle Pole Stability.
Cytoskeleton (Hoboken)
March 2025
Biology Department, Mount Saint Vincent University, Halifax, Canada.
The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule-associated protein required for correct mitotic spindle formation. To better understand the contribution of Asp to microtubule organization during spindle formation, we reverse-engineered flies to express a version of Asp (Asp), predicted to have lost its ability to bind the phosphatase trimer PP2A-B56.
View Article and Find Full Text PDFDifferences in Formation of Prepuce and Urethral Groove During Penile Development Between Guinea Pigs and Mice Are Controlled by Differential Expression of Shh, Fgf10 and Fgfr2.
Cells
February 2025
Department of Biomedical Sciences, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
The penile tubular urethra forms by canalization of the urethral plate without forming an obvious urethral groove in mice, while the urethral epithelium forms a fully open urethral groove before urethra closure through the distal-opening-proximal-closing process in humans and guinea pigs. Our knowledge of the mechanism of penile development is mainly based on studies in mice. To reveal how the fully opened urethral groove forms in humans and guinea pigs, we compared the expression patterns and levels of key developmental genes using in situ hybridization and quantitative PCR during glans and preputial development between guinea pigs and mice.
View Article and Find Full Text PDFDeterminants of weight gain in pregnant women with hyperemesis gravidarum in Dire Dawa administration, Eastern Ethiopia: An unmatched case-control study.
Womens Health (Lond)
March 2025
Department of Laboratory Technology Science, School of Medicine, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia.
Background: Adequate gestational weight gain affects birth outcomes and increases the risk of non-communicable diseases later in life. Weight gain in pregnant Ethiopian women with hyperemesis gravidarum has not been investigated comprehensively.
Objective: To assess the determinants of weight gain in pregnant women with hyperemesis gravida in Dire Dawa Administration, Eastern Ethiopia.
Phenotypic Variability of Cowden Syndrome Within a Single Family: Impact on Diagnosis, Management and Genetic Counselling.
Balkan J Med Genet
December 2024
Clinical Genetics Outpatient Clinic, Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic", 11070 Belgrade, Serbia.
Cowden syndrome (CS) represents a rare autosomal dominant disorder caused by mutations in the gene located on chromosome 10q23.3. This entity belongs to the PTEN hamartoma tumor syndrome (PHTS) spectrum.
View Article and Find Full Text PDFSilencing of hindered flowering and boll cracking in upland cotton.
Front Plant Sci
February 2025
State Key Laboratory of Aridland Crop Science, College of Life Science and Technology, Gansu Agricultural University, Lanzhou, China.
The opening of cotton bolls is an important characteristic that influences the precocity of cotton. In the field, farmers often use chemical defoliants to induce cotton leaves to fall off earlier, thus accelerating the cracking of cotton bolls. However, the molecular mechanism of cotton boll cracking remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!