Investigating the swelling behavior of superabsorbent polymer microparticles (SAP-MPs) at a single-particle level using traditional methods is constrained by low resolution and insufficient real-time data, especially for particles smaller than 300 µm. To address these challenges, a novel microfluidic device capable is developed of real-time, high-precision single-particle analysis. This platform hydrodynamically traps individual SAP-MPs, enabling continuous monitoring of their swelling dynamics under controlled conditions. SAP-MPs with varying sizes (90-270 µm), crosslinker concentrations (0.25%0.98) and minimal equilibrium volumetric swelling ratio deviations (ΔVSR<4%), confirming diffusion as the primary swelling mechanism, particularly for smaller particles. Smaller SAP-MPs exhibited enhanced performance, with VSR of ≈140 m/m-40% higher than their larger counterparts-and swelling rates (SR) up to 10 m m ·s. This study establishes microfluidics as a transformative tool for single-particle characterization and provides insights into engineering hydrogels tailored for advanced applications in drug delivery, tissue engineering, and environmental sensing.

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.202500014DOI Listing

Publication Analysis

Top Keywords

swelling dynamics
8
situ investigation
4
investigation swelling
4
dynamics acrylamide-acrylic
4
acrylamide-acrylic acid
4
acid superabsorbent
4
superabsorbent microparticles
4
microparticles single
4
single particle
4
particle level
4

Similar Publications

Optimizing Recovery: Heliox Therapy for Post-extubation Stridor Management.

Cureus

February 2025

Pulmonary and Critical Care, BronxCare Health System, Bronx, USA.

Post-extubation stridor poses a significant challenge in critical care settings, often necessitating prompt intervention to prevent respiratory compromise and potential reintubation. This case report details the successful management of post-extubation stridor in a 55-year-old female patient with a complex medical history, using heliox therapy. Heliox, a gas mixture of helium and oxygen, has emerged as a novel therapeutic option in such scenarios, owing to its ability to reduce airway resistance and improve gas flow dynamics.

View Article and Find Full Text PDF

Edema, characterized by the accumulation of interstitial fluid, poses significant challenges in various pathological conditions. Lymphangiogenesis is critical in edema clearance, and delayed or inadequate lymphatic responses significantly hinder healing processes. However, real-time observation of dynamic changes in lymphangiogenesis during tissue repair in animal models has been challenging, leaving the mechanisms behind compensatory lymphatic activation for edema clearance largely unexplored.

View Article and Find Full Text PDF

Investigating the swelling behavior of superabsorbent polymer microparticles (SAP-MPs) at a single-particle level using traditional methods is constrained by low resolution and insufficient real-time data, especially for particles smaller than 300 µm. To address these challenges, a novel microfluidic device capable is developed of real-time, high-precision single-particle analysis. This platform hydrodynamically traps individual SAP-MPs, enabling continuous monitoring of their swelling dynamics under controlled conditions.

View Article and Find Full Text PDF

Spinal cord injury (SCI) initiates a complex cascade of chemical and biophysical phenomena that result in tissue swelling, progressive neural degeneration, and formation of a fluid-filled cavity. Previous studies show fluid pressure above the spinal cord (supraspinal) is elevated for at least 3 days after injury and contributes to a phase of damage called secondary injury. Currently, it is unknown how fluid forces within the spinal cord itself (interstitial) are affected by SCI and if they contribute to secondary injury.

View Article and Find Full Text PDF

Synergistic adhesion enhancement of double-crosslinking chitosan hydrogel via catechol-Fe coordination and Schiff base.

Carbohydr Polym

May 2025

Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, PR China; Laboratory of Dynamics and Extreme Characteristics of Promising Nanostructured Materials, Saint Petersburg State University, St. Petersburg 199034, Russia. Electronic address:

Ionic crosslinking and Schiff base are employed to construct hydrogel wound dressings. However, the contributions of these crosslinking to the swelling behavior and adhesion performance of hydrogels are still unclear. Here, double-crosslinking chitosan hydrogel (DCH) is designed via catechol-Fe coordination and Schiff base between catechol modified chitosan and oxidized chitosan.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!