Bacterial vaginosis (BV) is characterised by a polymicrobial biofilm forming on the vaginal epithelium. In this study, we have developed a host-pathogen model of BV to replicate disease. We demonstrated tissue colonisation by four key vaginal pathobionts that formed metronidazole tolerant biofilms, with subtle changes in cytotoxicity and inflammation.
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Combatting antibiotic resistance in Gardnerella vaginalis: A comparative in silico investigation for drug target identification.
PLoS One
March 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Gardnerella vaginalis is the most frequently identified bacterium in approximately 95% of bacterial vaginosis (BV) cases. This species often exhibits resistance to multiple antibiotics, posing challenges for treatment. Therefore, there is an urgent need to develop and explore alternative therapeutic strategies for managing bacterial vaginosis.
View Article and Find Full Text PDFVaginal Prevotella timonensis Bacteria Enhance HIV-1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets.
Eur J Immunol
March 2025
Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Young females are at high risk of acquiring HIV-1 infections and an imbalance in the vaginal microbiome enhances susceptibility to HIV-1 infection. More insights into the underlying mechanisms could open up new strategies to prevent HIV-1 acquisition and dissemination. Here, we investigated the effect of anaerobic bacteria associated with bacterial vaginosis (BV) on HIV-1 transmission by two distinct dendritic cell (DC) subsets, that is, inflammatory monocyte-derived DCs (moDCs) and primary CD1c DCs.
View Article and Find Full Text PDFEvaluating the epidemiology of vaginitis in a contemporary cohort: a population-based study.
Front Public Health
March 2025
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Introduction: Bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and (TV) commonly cause infectious vaginitis in women, especially those of reproductive age. Characterization of the epidemiology of infectious vaginitis in a contemporary population-based cohort was done to determine the longitudinal age-standardized and sex-based testing, positivity, and incidence rates and ratios of infectious vaginitis in a large Canadian healthcare region.
Methods: We conducted a population-based cohort study from March 2015 through March 2018 using the Alberta Precision Laboratories (APL) microbiology database.
Development of a polymicrobial host-bacterial interface biofilm model for bacterial vaginosis.
Anaerobe
March 2025
Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow, G4 0BA, United Kingdom. Electronic address:
Bacterial vaginosis (BV) is characterised by a polymicrobial biofilm forming on the vaginal epithelium. In this study, we have developed a host-pathogen model of BV to replicate disease. We demonstrated tissue colonisation by four key vaginal pathobionts that formed metronidazole tolerant biofilms, with subtle changes in cytotoxicity and inflammation.
View Article and Find Full Text PDFBiological, Clinical, and Sociobehavioral Factors Associated with Disproportionate Burden of Bacterial Vaginosis in the United States: A Comprehensive Literature Review.
J Womens Health (Larchmt)
March 2025
Organon, Jersey City, New Jersey, USA.
Bacterial vaginosis (BV), a common gynecological infection characterized by reduced lactic acid-producing bacteria and increased anerobic bacteria in the vaginal microbiome, is associated with adverse health outcomes. A PubMed search for English-language articles about BV in the USA and factors contributing to disparities in BV risk, with an emphasis on the role of the vaginal microbiome, published from August 2012 to August 2022, identified 760 articles. Among the 52 articles meeting the prespecified criteria, BV prevalence varied among different populations and disproportionately impacted Black women (49-51%), Hispanic ethnicity (32-43%), and women of reproductive age (30%).
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