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Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma.
Elife
March 2025
Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Background: Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). The tumor immune microenvironment (TIME) and tumor heterogeneity are recognized as pivotal factors in cancer progression and therapy. However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood.
View Article and Find Full Text PDFA Novel Approach for Suprachoroidal Space Injection: An Experimental Evaluation.
Curr Eye Res
March 2025
Department of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: This study aims to describe an innovative suprachoroidal space injection technique using a combination of 30 G and 22 G needles attached to a 1 ml injector. The efficacy and applicability of this technique in suprachoroidal injections are evaluated.
Methods: In this study, we conducted both and injection experiments using isolated porcine eyes and live SD rats, respectively.
Precision Medicine Is in the Eye of the Beholder.
Circ Heart Fail
March 2025
Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Sex differences in the risk factors, diagnosis, treatment, and outcomes of patients with cardiovascular disease have been well described; however, the bulk of the literature has focused on heart disease in women. Data on sex differences in peripheral vascular disease are ill defined, and there is a need to report and understand those sex-related differences to mitigate adverse outcomes related to those disparities. Although peripheral vascular disease is a highly diverse group of disorders affecting the arteries, veins, and lymphatics, this scientific statement focuses on disorders affecting the peripheral arteries to include the aorta and its branch vessels.
View Article and Find Full Text PDFLarge-scale evidence of a general disease ('') factor accounting for both mental and physical health disorders in different age groups.
Psychol Med
March 2025
Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton, UK.
Background: It is unknown whether there is a general factor that accounts for the propensity for both physical and mental conditions in different age groups and how it is associated with lifestyle and well-being.
Methods: We analyzed health conditions data from the Millennium Cohort Study (MCS) (age = 17; N = 19,239), the National Child Development Study (NCDS) (age = 44; N = 9293), and the English Longitudinal Study of Ageing (ELSA) (age ≥ 50; N = 7585). The fit of three Confirmatory Factor models was used to select the optimal solution by Comparative Fit Index, Tucker-Lewis Index, and Root Mean Square Error of Approximation.
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