Background: Published studies rarely assess associations between trajectories of drinking and mortality.
Methods: We aimed to assess associations between long-term sex-specific drinking trajectories and all-cause and disease-specific mortality for 39 588 participants (23 527 women; 16 061 men) enrolled in the Melbourne Collaborative Cohort Study in 1990-94 aged 40-69 years. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause, cardiovascular disease- and cancer-specific mortality in relation to group-based alcohol intake trajectories.
Results: There were 7664 deaths (1117 cardiovascular; 2251 cancer) in women over 595 456 person-years, and 7132 deaths (1283 cardiovascular; 2340 cancer) in men over 377 314 person-years. We identified three distinct group-based alcohol intake trajectories for women: 'lifetime abstention', 'stable light', and 'increasing moderate'; and six for men: 'lifetime abstention', 'stable light', 'stable moderate', 'increasing heavy', 'early decreasing heavy', and 'late decreasing heavy'. We observed 9%-12% lower all-cause mortality, driven by associations with cardiovascular disease-specific deaths, for 'stable light' (women: HR 0.91; 95% CI 0.87-0.96; men: HR 0.88; 95% CI 0.82-0.94) and 'stable moderate' (HR 0.88; 95% CI 0.81-0.96) drinking, compared with 'lifetime abstention'. In contrast, all-cause mortality was 18%-21% higher for 'early decreasing heavy' (HR 1.18; 95% CI 1.05-1.32) and 'late decreasing heavy' (HR 1.21; 95% CI 1.04-1.40) drinking, and cancer-specific mortality 19%-37% higher for 'increasing moderate' (HR 1.19; 95% CI 1.00-1.43), 'early decreasing heavy' (HR 1.34; 95% CI 1.10-1.64), and 'late decreasing heavy' (HR 1.37; 95% CI 1.06-1.77) drinking.
Conclusions: Our findings highlight the importance of avoiding higher levels of alcohol intake during the life course to reduce all-cause and cancer-specific mortality.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ije/dyaf022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extent of natural soil cadmium, its bioavailability, and pollution treat analysis in the agroforestry systems of the Gedeo Zone of southern Ethiopia.
Heliyon
February 2025
Center of Excellence for Soil and Fertilizer Research in Africa, College of Agriculture and Environmental Science, Mohammed VI Polytechnic University, Benguerir, Morocco.
The research objectives were to determine extent of soil cadmium (Cd) in the major soil types of the Gedeo Zone of Ethiopia thereby assessing the pollution risk on the environmental health. Four profile pits representing Luvisols, Nitisols, Cambisols, and Leptosols, were excavated and soil samples were collected. Total and available Cd, Cu, Zn, and Mn, including other major soil physicochemical properties, were analyzed in the lab.
View Article and Find Full Text PDFEffects of alpha-ketoisocaproate in oxidative stress-induced C2C12 myotubes via inhibition of p38 MAPK and ERK1/2.
Biochem Biophys Rep
March 2025
Department of Anatomy, Korea University College of Medicine, Seoul, Republic of Korea.
Sarcopenia is an age-related muscle atrophy characterized by decreased muscle mass and function. However, potential treatments to alleviate sarcopenia remain limited. In this study, we investigated the effects of α-ketoisocaproate (KIC) on C2C12 differentiation and reactive oxygen species (ROS)-induced atrophy in C2C12 myotubes.
View Article and Find Full Text PDFSpatiotemporal variations and influencing factors of heavy metals of topsoil in Pearl River Basin, China.
Environ Res
March 2025
Institute of Geophysical and Geochemical Exploration, Chinese Academy of Geological Sciences, Langfang, Hebei 065000, China; UNESCO International Centre on Global-scale Geochemistry, Langfang, Hebei 065000, China.
This study investigates the spatiotemporal variations and influencing factors of topsoil heavy metals in the Pearl River Basin by utilizing data from the 2000s to the 2010s obtained from China Geochemical Baselines project (CGB1: 2008-2012; CGB2: 2015-2019), alongside geostatistics methods and a modified absolute principal component scores-multiple linear regression (APCS-MLR) model. The results indicate that the median concentrations of As, Cd, Pb, Zn, Cu, Cr, Ni, and Hg exhibited a decreasing trend from the CGB1 to CGB2. Notably, As concentrations decreased the most, with a reduction percentage of 24.
View Article and Find Full Text PDFEnhancement of the phytoremediation performance in heavy metal-contaminated soil using a multifunctional EPS-producing bacterium Kosakonia sp. W18.
Environ Res
March 2025
Department of Environmental Science and Engineering, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address:
The use of exopolysaccharide (EPS)-producing bacteria for the phytoremediation of heavy metal-contaminated soil is emerging as a promising approach. This study explores the potential of Kosakonia sp. W18, an EPS-producing bacterium isolated from Suaeda japonica habitat, in the phytoremediation of heavy metal-contaminated soils.
View Article and Find Full Text PDFAlcohol consumption trajectories over the life course and all-cause and disease-specific mortality: the Melbourne Collaborative Cohort Study.
Int J Epidemiol
February 2025
Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.
Background: Published studies rarely assess associations between trajectories of drinking and mortality.
Methods: We aimed to assess associations between long-term sex-specific drinking trajectories and all-cause and disease-specific mortality for 39 588 participants (23 527 women; 16 061 men) enrolled in the Melbourne Collaborative Cohort Study in 1990-94 aged 40-69 years. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause, cardiovascular disease- and cancer-specific mortality in relation to group-based alcohol intake trajectories.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!