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Critical Roles of VEGFR1, VEGFR2, VEGFR3, BAX, and BCL-2 in the Pathogenesis of Varicose Veins: Unveiling Molecular Mechanisms.
Am J Mens Health
March 2025
Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Varicocele is characterized by the abnormal dilation of veins within the testicular pampiniform plexus, contributing to inflammation, pain, and infertility in males. The precise roles of vascular endothelial growth factor receptors (VEGFRs), B-cell lymphoma 2 (BCL-2), and BCL-2-associated X-protein (BAX) in the pathology of varicocele still need to be clarified. This study sought to investigate the protein expression levels of VEGFR1, VEGFR2, VEGFR3, BCL-2, and BAX in varicose and healthy vessels from patients diagnosed with varicocele.
View Article and Find Full Text PDFAdvancing the Study of Maternal Prenatal Stress Phenotypes and Infant Temperament Outcomes.
Dev Psychobiol
March 2025
Department of Psychology, Washington State University, Pullman, Washington, USA.
Exposure to the in utero environment provides offspring risk or protection with respect to postpartum development and health across the lifespan. We used latent profile analysis (LPA), considering self-report and physiological indicators to assess the influence of maternal prenatal stress/distress on infant temperament. We predicted that participants who reported greater prenatal stress/distress would have infants with less optimal temperament characteristics (e.
View Article and Find Full Text PDFGestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma'anshan Birth Cohort Study in China.
J Am Heart Assoc
March 2025
Department of Maternal, Child and Adolescent Health, School of Public Health Anhui Medical University Hefei Anhui China.
Background: Animal studies suggest cardiovascular systems may be primary targets for barium toxicity. This study aims to examine longitudinal associations of prenatal and early childhood barium exposure with cardiometabolic risk (CMR) in preschoolers.
Methods And Results: We determined serum or plasma barium concentrations during 3 trimesters, delivery, and early childhood (5 years) from 2291 mother-child dyads within the Ma'anshan Birth Cohort.
Loss of N-6 adenine-specific DNA methyltransferase 1 leads to meiotic prophase abnormalities and male sub-fertility in mice.
Biol Reprod
March 2025
The Institute of Cardiovascular Sciences, School of Basic Medical Sciences; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Mammalian sexual reproduction critically relies on the generation of haploid gametes following a specialized cell division process known as meiosis. Here, we demonstrate that N-6 Adenine-Specific DNA methyltransferase 1 (N6AMT1) plays a crucial role in the progression of meiosis during spermatogenesis, as follows. N6AMT1 was expressed in germ cells throughout the entire process of spermatogenesis, with a peak in mRNA levels in spermatocytes at the prophase I stage of meiosis.
View Article and Find Full Text PDF'Too much, too little' - heat wave impact during pregnancy and the need for adaptation measures.
Glob Health Action
December 2025
Department of Epidemiology and Global Health, Medical Faculty, Umeå University, Umeå, Sweden.
The balls are rolling for climate change, with increasing vulnerability to women and children related to climate extreme events. Recent evidence has shown that acute exposure to heat wave during pregnancy can be associated with adverse health outcomes in childhood, with the risk being significantly higher among socially disadvantaged population, despite their lack of contribution to global carbon dioxide emissions and the rising global ambient temperature. This unequal impact requires utmost attention to develop tools, establish interdisciplinary teams, and to implement evidence-based interventions for the betterment of women and children in climate-vulnerable populations.
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