J Radiol Prot
GMS Abingdon, Tamarisk, Radley Road, OX14 3PP, Abingdon, OX14 3PP, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Published: March 2025
The Norwegian government has maintained a plan of action on nuclear safety and security for over 25 years. The need for such a plan grew from extensive nuclear activities during the Cold War, both civil and military, that led eventually to significant amounts of radioactive waste and nuclear material being stored in unsafe conditions in northwest Russia. As part of the program to implement the plan of action, the Norwegian Radiation and Nuclear Safety Authority has maintained a program of bilateral regulatory cooperation with corresponding authorities in countries of the former Soviet Union for over 25 years. This paper reviews the background to that regulatory program, identifies the main radiologically hazardous objects and the related regulatory challenges, and then documents how bilateral cooperation has contributed to the substantial progress made in risk reduction. The review then considers how bilateral work has contributed to and benefitted from sharing results and experience with international partners and draws conclusions and lessons for future work. The primary conclusion is that bilateral regulatory cooperation has supported reduction of radiation and nuclear risks at a range of complex legacy sites and facilities in countries of the former Soviet Union. Key to this process has been a clear strategy to help build and maintain an up-to-date, robust and independent regulatory process. Only with well-coordinated regulatory bodies with clear responsibilities and functions is it possible to address the diverse threats effectively. Among the most radiologically significant sites and facilities where risk has been significantly reduced or eliminated are the Lepse spent fuel and radioactive waste storage vessel, the site for temporary storage for spent fuel and radioactive waste at Andreeva Bay, and the very large radio-isotope thermo-electric generators sources previously used in navigational devices all across the Russian arctic coastline. Noting the clear potential for transboundary impacts, this represents a substantial regional benefit. .
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http://dx.doi.org/10.1088/1361-6498/adbe82 | DOI Listing |
J Immunol
March 2025
Department of Immunology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Mast cells (MCs) play a central role in allergic immune responses. MC activation is regulated by several inhibitory immunoreceptors. The CD300 family members CD300a and CD300lf recognize phospholipid ligands and inhibit the FcεRI-mediated activating signal in MCs.
View Article and Find Full Text PDFCytoskeleton (Hoboken)
March 2025
Biology Department, Mount Saint Vincent University, Halifax, Canada.
The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule-associated protein required for correct mitotic spindle formation. To better understand the contribution of Asp to microtubule organization during spindle formation, we reverse-engineered flies to express a version of Asp (Asp), predicted to have lost its ability to bind the phosphatase trimer PP2A-B56.
View Article and Find Full Text PDFCell Rep
March 2025
Institute of Immunology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany; Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany. Electronic address:
The transcription factor interferon regulatory factor 4 (IRF4) is crucial for the fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing group of immunomodulatory regulatory T (Treg) cells. However, the molecular mechanisms of how IRF4 steers diverse transcriptional programs in Th17 and Treg cells are far from being definitive. Here, we integrated data derived from affinity-purification and full mass-spectrometry-based proteome analysis with chromatin immunoprecipitation sequencing.
View Article and Find Full Text PDFInflamm Bowel Dis
March 2025
Integrative Genomics Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Basque Country, Spain.
Background: MicroRNAs (miRNAs) play a key role in regulating gene expression in Crohn's disease (CD). Although several studies have identified miRNAs with biomarker potential, an exhaustive characterization of the miRNAome in CD is still lacking. We performed the largest miRNA profiling effort to date to analyze miRNA variability across intestinal tissues, disease activity status, and infliximab treatment in CD.
View Article and Find Full Text PDFChem Biol Interact
March 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address:
Human CYP1A1 and CYP1B1 are two important enzymes for the hydroxylation of estrogens. In this study, we aimed to investigate the potential role for FXR receptor in the regulation of CYP1A1 and CYP1B1 expressions and activities. First, pharmacokinetic analysis was conducted in male wild-type and Fxr mice after intraperitoneal dosing of exogenous estradiol.
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