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Roundtable: Expansion in early treatment.
J Clin Orthod
December 2024
Private Practice of Orthodontics in Tamburrino Family Orthodontics, Kennett Square, PA.
Clinical and Socioeconomic Burden of Retinal Diseases: Can Biosimilars Add Value? A Narrative Review.
Ophthalmol Ther
February 2025
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Retinal diseases, such as neovascular age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion, pose a significant global burden on individuals, families, and healthcare systems. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy has become the standard treatment for retinal diseases, improving clinical outcomes, while delaying disease progression. Although effective, biologics are associated with high costs, which can lead to underutilisation and, consequently, suboptimal patient treatment outcomes, further contributing to healthcare costs.
View Article and Find Full Text PDFAccessing Azetidines through Magnesium-Mediated Nitrogen Group Transfer from Iminoiodinane to Donor-Acceptor Cyclopropanes.
Angew Chem Int Ed Engl
February 2025
Department of Chemistry, New York University, New York, New York, 10003, United States.
Herein, we report a Lewis acid-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. This protocol operates under mild, transition-metal-free conditions, and showcases excellent chemoselectivity, along with broad functional group tolerance. We report for the first time that challenging alkyl donor-acceptor cyclopropanes can undergo ring expansion leading to aliphatic azetidines without relying on external oxidants or precious transition-metal catalysts.
View Article and Find Full Text PDFMeeting the accreditation standard through implementation of a multiprogram residency advisory committee and ongoing quality improvement.
Am J Health Syst Pharm
November 2024
Pharmacy, VA Northeast Ohio Healthcare System, Cleveland, OH.
Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFPolicy Actors' Perceptions of Conflicts of Interest and Alcohol Industry Engagement in UK Policy Processes.
Int J Health Policy Manag
April 2024
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Background: Alcohol industry organisations occupy a prominent position in UK alcohol policy, but their involvement has been contested by public health bodies on the basis that a conflict of interest (COI) exists between their economic objectives and those of public health. There are ongoing debates in the research literature about how to conceptualise COI and mitigate this in health research and practise. However, less attention has been paid to these issues in relation to the alcohol industry specifically.
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