Purpose: To compare the rate of endothelial cell density (ECD) loss in patients undergoing pars plana vitrectomy (PPV) with silicone oil (SO) tamponade, focusing on differences between rhegmatogenous retinal detachment (RRD) and tractional retinal detachment (TRD) cases.
Methods: A retrospective analysis was conducted on 427 eyes from patients with RRD (n=293) and TRD (n=134) who underwent PPV with SO tamponade. ECD changes were recorded, and the impact of factors such as age, gender, surgical technique, SO emulsification, tamponade duration, and postoperative intraocular pressure (IOP) were evaluated using univariate and multivariate regression models.
Results: TRD patients showed a significantly higher ECD loss (9.17%) compared to RRD patients (3.39%). ECD loss was particularly severe in patients undergoing combined anterior and posterior surgeries, as the vitrectomy in combination with phacoemulsification (VCP) group showed a loss of 6.85% and the intraocular lens (IOL) group exhibited 6.48%. Multivariate regression revealed a 1% increase in ECD loss for every 8-year increase in age (P=0.006). No significant correlation between transient high intraocular pressure (THIOP) and ECD loss.
Conclusion: TRD patients are at greater risk of ECD loss following PPV with SO tamponade, particularly in cases involving combined surgeries. Advanced age and the absence of a natural lens were associated with greater ECD loss. Maintaining postoperative intraocular pressure (IOP) below 40 mmHg is considered safe for ECD.Further investigation into the mechanisms of SO-related endothelial damage is needed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/IAE.0000000000004455 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endothelial cell loss post-pars plana vitrectomy with silicone oil tamponade: a comparative study of rhegmatogenous and tractional retinal detachments.
Retina
March 2025
School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Purpose: To compare the rate of endothelial cell density (ECD) loss in patients undergoing pars plana vitrectomy (PPV) with silicone oil (SO) tamponade, focusing on differences between rhegmatogenous retinal detachment (RRD) and tractional retinal detachment (TRD) cases.
Methods: A retrospective analysis was conducted on 427 eyes from patients with RRD (n=293) and TRD (n=134) who underwent PPV with SO tamponade. ECD changes were recorded, and the impact of factors such as age, gender, surgical technique, SO emulsification, tamponade duration, and postoperative intraocular pressure (IOP) were evaluated using univariate and multivariate regression models.
The leukocyte common antigen related receptor (LAR) is a member of the LAR receptor protein tyrosine phosphatase (RPTP) family of synaptic adhesion molecules that contribute to the proper alignment and specialization of synaptic connections in the mammalian brain. LAR-RPTP members have been genetically associated with neuropsychiatric disorders, but the molecular consequences of genetic perturbations of LAR remain unstudied. Using exome sequencing data from psychiatric patients and controls, we identify rare missense variants of LAR that render the extracellular domain (ECD) unstable and susceptible to proteolytic cleavage.
View Article and Find Full Text PDFLong-term outcome and related-risk factors in Implantable Collamer Lens (ICL) Implantation of high myopia.
Korean J Ophthalmol
February 2025
Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital.
Purpose: To investigate the long-term efficacy and safety of posterior chamber implantable collamer lens (ICL) implantation in high myopia, and the risk factors associated with endothelial cell loss (ECL) or cataract development.
Methods: Medical records of 66 eyes of 37 patients who underwent ICL implantation for high myopia were retrospectively analyzed with a mean follow-up of 12 years. Changes in LogMAR best corrected visual acuity (BCVA), intraocular pressure (IOP), refractive power, and endothelial cell density (ECD) over time were analyzed with the incidence of cataract and IOP elevation.
Effect of femtosecond laser-assisted cataract surgery for cataracts after pars plana vitrectomy: a prospective randomized controlled study.
BMC Ophthalmol
February 2025
Chengdu Aidi Eye Hospital, No. 45, West Section 2, Ring 2 Road, Qingyang District, Chengdu, Sichuan, China.
Objective: To compare the efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) in treating postvitrectomy cataracts.
Methods: Prospective randomized controlled study. Patients who underwent cataract surgery after pars plana vitrectomy (PPV) were randomly divided into the FLACS group and the CPS group.
Trichothecroamides A‒F, antifungal amides from potato associated fungus Trichothecium crotocinigenum.
Phytochemistry
June 2025
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China; International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, Wuhan, 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan, 430074, China. Electronic address:
Potato is the most important non-cereal food crop in the world. Phytophthora infestans and Rhizoctonia solani are responsible for the cause of late blight and black scurf of potato, respectively, which take a decline of potato production and serious economic loss to the producers. As a continuation of the search of natural fungicides from the secondary metabolites of potato associated fungus Trichothecium crotocinigenum, five previously undescribed amide derivatives trichothecroamides A‒E, one previously undescribed cyclopeptide trichothecroamide F, together with three known cyclopeptides, have been obtained.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!