Background: Implementing the thermoplastic mask as a treatment option in Gamma Knife radiosurgery (GKRS) has madethe discussion of the relative benefits of frame- or mask-based fixation for treatment a frequent occurence. Based on a case review, the authors discuss factors that need to be understood and considered by the treating team.
Observations: The authors describe the case of an 81-year-old patient with pleomorphic dermal sarcoma that extended to and infiltrated the dura mater, who underwent extensive resection requiring a skin flap. Adjuvant GKRS was recommended. The fixation type was limited by the extent of the flap that would cause a suboptimal frame fixation (less than 3 points) and its compression by the lateral aspect of the mask. Creating a tailored mask with its lateral table-fixation cut out was required. To guarantee appropriate immobilization, an understanding of the primary stability points of the mask was needed, which was achieved by monitoring the intrafraction motion. The patient tolerated the treatment delivery well, with minimal movement and proper positioning maintenance.
Lessons: The option of a rigid frame or a mask allows for personalized treatment for each patient based on their unique needs. Understanding the advantages and limitations of each modality allowed a safe and precise treatment for the described case. https://thejns.org/doi/10.3171/CASE24852.
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http://dx.doi.org/10.3171/CASE24852 | DOI Listing |
Elife
March 2025
Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Background: Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). The tumor immune microenvironment (TIME) and tumor heterogeneity are recognized as pivotal factors in cancer progression and therapy. However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood.
View Article and Find Full Text PDFNat Prod Rep
March 2025
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, 117543, Singapore.
Covering: up to early 2025Privileged compound classes of anti-inflammatory natural products are those where there are many reported members that possess anti-inflammatory properties. The identification of these classes is of particular relevance to drug discovery, as they could serve as valuable starting points in developing effective and safe anti-inflammatory agents. The privileged compound classes of natural products include the polyphenols, coumarins, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids, each offering a variety of molecular scaffolds and functional groups that enable diverse interactions with biological targets.
View Article and Find Full Text PDFPhysiother Theory Pract
March 2025
Physiotherapy Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Background: The association of different sensory inputs enhances brain plasticity in patients after stroke, but no studies have associated Action Observation Training (AOT) delivered in immersive virtual reality (VR) with Focal Vibration (FV) to elicit a kinesthetic illusion coherent with the observed task to improve motor function.
Objective: The study aimed to evaluate the feasibility of AOT delivered in immersive VR integrated with FV of upper limb muscles on manual dexterity in patients with chronic stroke.
Methods: A single-subject study was conducted (A-B design).
Ann Med
December 2025
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Aim: This review aims to summarize the epidemiology, pathogenesis, clinical features, management, prognosis and regression of Neonatal lupus erythematosus (NLE) with a view to providing directions for standardized diagnosis, treatment and further research.
Methods: We conducted a comprehensive literature review of NLE. NLE-related peer-reviewed papers were searched through PubMed/Medline were searched up to November 2024.
JBI Evid Synth
March 2025
Health Quality Programs, Queen's University, Kingston, Ontario, Canada.
Objectives: The objective of this review is to identify, appraise, and synthesize available evidence on the experiences of informal caregivers providing HIV and/or AIDS care and the experiences of care received by people living with HIV and/or AIDS (PLHIV) in sub-Saharan Africa.
Introduction: PLHIV share the burden of the disease with their informal caregivers throughout their lives. Experiences of HIV- and/or AIDS-related caregiving and care receiving have a significant impact on the treatment and physiological health outcomes of both care receivers and caregivers.
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