Background: Hamartomas of the floor of the fourth ventricle (HFFVs) are rare lesions that cause a variety of symptoms, including hemifacial spasm (HFS). When symptomatic, these deep-seated lesions are traditionally treated via open surgical approaches. The authors describe successful laser interstitial thermal therapy (LITT) of an HFFV causing intractable HFS.
Observations: A healthy 19-month-old girl presented with right HFS, present since birth, occurring continuously throughout the day. MRI revealed a right HFFV. Following an unsuccessful trial of medical treatment and serial imaging to rule out a neoplastic process, she underwent LITT of the HFFV with immediate resolution of her facial spasm. She was discharged on postoperative day 1 with durability of her treatment at the 1-year follow-up and no neurological complications.
Lessons: Laser ablation of HFFVs provides a well-tolerated, durable treatment option for HFFVs in pediatric patients. https://thejns.org/doi/10.3171/CASE24721.
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http://dx.doi.org/10.3171/CASE24721 | DOI Listing |
J Cosmet Laser Ther
March 2025
Department of Dermatology, The University of California, San Diego, USA.
Delayed inflammatory nodules (DIN) after soft-tissue filler injection may occur after infections, vaccinations, or procedures. We report a DIN from predominantly low-molecular-weight HA (PLMW-HA) filler secondary to COVID-19 infection that was resistant to conservative management, requiring intralesional combination therapy with triamcinolone, 5-fluorouracil, and recombinant human hyaluronidase for resolution.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: () adheres to the surface of medical devices, forming highly drug-resistant biofilms, which has made the development of novel antibacterial agents against and its biofilms a key research focus. By drug repurposing, this study aims to explore the combinational antimicrobial effects between pinaverium bromide (PVB), a -type calcium channel blocker, and oxacillin (OXA) against .
Methods: Clinical isolates of were collected from January to September 2022 at the Department of Clinical Laboratory of the Third Xiangya Hospital, Central South University.
Exp Cell Res
March 2025
Central Labs, King Khalid University, AlQura'a, Abha, Saudi Arabia; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. Electronic address:
CS1 (SLAMF7), a pivotal immune receptor, plays a dual role in modulating immune responses in autoimmune diseases and cancer. In autoimmunity, aberrant CS1 signaling contributes to the activation of autoreactive lymphocytes, driving pathologies such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Conversely, in oncology, CS1 serves as a promising immunotherapeutic target, exemplified by the efficacy of the monoclonal antibody Elotuzumab in multiple myeloma.
View Article and Find Full Text PDFJ Dermatolog Treat
December 2025
Department of Cosmetology, Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang, China.
Background: Melasma is a common pigmentary skin disorder. Q-switched Nd:YAG laser therapy is commonly used, but its efficacy is limited. PhotoAcoustic Technology Pulse (PTP) mode is a newer technology that may enhance treatment outcomes.
View Article and Find Full Text PDFJ Surg Res
March 2025
Department of Vascular Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China. Electronic address:
Introduction: This study aimed to assess the midterm efficacy and symptoms of sclerosing foam combined with endovenous laser ablation in treating lower-extremity varicose veins.
Methods: This study analyzed 838 patients (985 limbs) with varicose veins in one or both lower extremities, treated at our center from September 2020 to June 2022. All patients underwent sclerosing foam combined with endovenous laser ablation.
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