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Exploring the impact of gender-related variables on health measures and perceived stress.
Front Psychol
February 2025
Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
Introduction: Despite its relevance for health outcomes, only recently gender has begun to be explored in the scientific literature, typically using a rigid binary framework. To tackle this, the Stanford Gender-related Variables for Health Research (GVHR) was developed to analyze gender from a multidimensional perspective. We aim to use our Portuguese version of the GVHR and analyze its association with health outcomes, including perceived stress.
View Article and Find Full Text PDFTraumatic stress-enhanced ethanol drinking: Sex, but not stress responsivity, alters sensitivity to the effects of a CRF-R1 antagonist and a GPR39 agonist in mice.
Alcohol Clin Exp Res (Hoboken)
March 2025
Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Background: Predator stress (PS) is used to model trauma leading to post-traumatic stress disorder, and it increases ethanol drinking in a proportion of male and female rodents. The goals of the present studies were to identify male and female mice with prior binge drinking experience that exhibited sensitivity and resilience to PS-enhanced drinking and then to test two target molecules (corticotropin releasing factor receptor 1 [CRF-R1] antagonist NBI-27914 [NBI] and G-protein coupled receptor 39 [GPR39] agonist TC-G 1008 [TC-G]) for their ability to selectively reduce PS-enhanced drinking.
Methods: Adult male and female C57BL/6J mice received seven binge ethanol sessions, a period of abstinence, and acclimation to lickometer chambers to examine the effects of NBI or TC-G on stress-associated drinking.
Global scientific research landscape on binge drinking: a comprehensive bibliometric and visualization analysis of trends, collaborations, and future directions.
Subst Abuse Treat Prev Policy
March 2025
Poison Control and Drug Information Center (PCDIC), An-Najah National University, Nablus, 44839, Palestine.
Background: Binge drinking constitutes a significant public health concern. Defined as the consumption of five or more alcoholic beverages on a single occasion, binge drinking leads to acute cognitive and motor impairments and is associated with a multitude of detrimental health consequences. Therefore, the aim of this study was to analyse globally published peer-reviewed literature on binge drinking.
View Article and Find Full Text PDFALDH2 deficiency and alcohol intake in the U.S.: Opportunity for precision cancer prevention.
Cancer Epidemiol Biomarkers Prev
March 2025
University of California, Irvine, Irvine, CA, United States.
Background: Alcoholic beverages and the main metabolite of alcohol, acetaldehyde, are known carcinogens. A genetic variant in aldehyde dehydrogenase 2 (ALDH2, G>A, rs671) leads to decreased efficiency in metabolizing acetaldehyde and is associated with increased cancer risk. Since alcohol consumption is a modifiable risk factor for various cancers, the identification of ALDH2 deficiency presents an opportunity for precision cancer prevention.
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