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UnifiedGreatMod: A New Holistic Modelling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale.
Bioinformatics
March 2025
Department of Computer Science, University of Turin, Torino, 10123, Italy.
Motivation: Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognisable from the biological and clinical community is the possibility of quickly inspecting the whole system, bearing in mind the different granularity levels of its components. This holistic view of system behaviour expands the evolution study by identifying the heterogeneous behaviours applicable, for example, to the cancer evolution study.
View Article and Find Full Text PDFCoping with chronic periprosthetic joint infection after failed revision of total knee and hip arthroplasty: a qualitative study on patient's experiences in treatment and healing.
PLoS One
March 2025
Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Periprosthetic joint infections (PJI), along with the extensive medical and surgical interventions required for treatment, impose a substantial psychological burden on patients. Given the need for patients to adapt to long-term physical limitations and ongoing medical challenges, this qualitative study aims to explore the nature of psychological coping amongst patients with chronic cases of PJI. A total of 18 patients (8 men and 10 women, aged 55 to 92) who underwent a total knee or hip arthroplasty revision due to chronic PJI were recruited at a single academic institution between August 2022 and July 2023.
View Article and Find Full Text PDFA patient first perspective of sleep disturbance across therapeutic areas: a systematic literature review of qualitative studies.
Qual Life Res
March 2025
Digital Medicine Society, Boston, MA, USA.
Background: Sleep, a vital pillar of health, impacts daily functioning and overall quality of life. Despite extensive research on sleep disturbances within specific therapeutic areas (TAs), there's limited understanding of how these disturbances affect patients across multiple TAs. This systematic literature review adopts a patient-centered approach to explore the meaningful aspects of health and concepts of interest relating to sleep and sleep disturbances across a variety of TAs, utilizing qualitative research to bridge the gap between patient experiences and clinical measures.
View Article and Find Full Text PDFTRANSFORMING VETERINARIANS INTO INFLUENTIAL ORGANIZATIONAL PARTNERS USING COLLABORATIVE BUSINESS RISK ANALYSIS TO DRIVE ANIMAL WELL-BEING PROGRAMS.
J Zoo Wildl Med
March 2025
Disney's Animals, Science and Environment, Bay Lake, FL 32830, USA.
Traditionally, animal preventive medicine programs have been based on reducing health risks to individuals or groups of animals within a zoo or aquarium collection with an emphasis on transmissible pathogens of concern. An alternative risk analysis method of using animal health risks that impact a zoo or aquarium business to drive animal well-being program strategy is suggested. Business risk lenses of value to the individual organization are determined and weighted prior to use for risk analysis.
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